Tocolysis in the management of preterm prelabor rupture of membranes at 22–33 weeks of gestation: study protocol for a multicenter, double-blind, randomized controlled trial comparing nifedipine with placebo (TOCOPROM)

Tocolysis in the management of preterm prelabor rupture of membranes at 22–33 weeks of gestation: study protocol for a multicenter, double-blind, randomized controlled trial comparing nifedipine with placebo (TOCOPROM)

Abstract Background Preterm prelabor rupture of membranes (PPROM) before 34 weeks of gestation complicates 1% of pregnancies and accounts for one-third of preterm births. International guidelines recommend expectant management, along with antenatal steroids before 34 weeks and antibiotics. Up-to-dat...

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Bibliographic Details
Main Authors: Elsa Lorthe, Gilles Kayem, on behalf of the TOCOPROM Study Group and the GROG (Groupe de Recherche en Obstétrique et Gynécologie)
Format: Article
Language:English
Published: BMC 2021-09-01
Series:BMC Pregnancy and Childbirth
Subjects:
Tocolysis
Nifedipine
Randomized controlled trial
Pregnancy
Preterm birth
Preterm prelabor rupture of membranes
Online Access:https://doi.org/10.1186/s12884-021-04047-2

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