Metabolic syndrome in patients with first-ever ischemic stroke: prevalence and association with coronary heart disease
Abstract The metabolic syndrome (MetS) has been well linked with coronary heart disease (CHD) in the general population, but studies have rarely explored their association among patients with stroke. We examine prevalence of MetS and its association with CHD in patients with first-ever ischemic stro...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-17369-8 |
| _version_ | 1811222381495058432 |
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| author | Yajun Liang Zhongrui Yan Yanlei Hao Qiqi Wang Zuoji Zhang Rui She Peng Wang Yifeng Du Joseph TF Lau Joost Dekker Bo Bai Chengxuan Qiu |
| author_facet | Yajun Liang Zhongrui Yan Yanlei Hao Qiqi Wang Zuoji Zhang Rui She Peng Wang Yifeng Du Joseph TF Lau Joost Dekker Bo Bai Chengxuan Qiu |
| author_sort | Yajun Liang |
| collection | DOAJ |
| description | Abstract The metabolic syndrome (MetS) has been well linked with coronary heart disease (CHD) in the general population, but studies have rarely explored their association among patients with stroke. We examine prevalence of MetS and its association with CHD in patients with first-ever ischemic stroke. This hospital-based study included 1851 patients with first-ever ischemic stroke (mean age 61.2 years, 36.5% women) who were hospitalized into two university hospitals in Shandong, China (January 2016–February 2017). Data were collected through interviews, physical examinations, and laboratory tests. MetS was defined following the National Cholesterol Education Program (NCEP) criteria, the International Diabetes Federation (IDF) criteria, and the Chinese Diabetes Society (CDS) criteria. CHD was defined following clinical criteria. Data were analyzed using binary logistic regression models. The overall prevalence of MetS was 33.4% by NECP criteria, 47.2% by IDF criteria, and 32.5% by CDS criteria, with the prevalence being decreased with age and higher in women than in men (p < 0.05). High blood pressure, high triglycerides, and low HDL-C were significantly associated with CHD (multi-adjusted odds ratio [OR] range 1.27–1.38, p < 0.05). The multi-adjusted OR of CHD associated with MetS defined by the NECP criteria, IDF criteria, and CDS criteria (vs. no MetS) was 1.27 (95% confidence interval 1.03–1.57), 1.44 (1.18–1.76), and 1.27 (1.03–1.57), respectively. In addition, having 1–2 abnormal components (vs. none) of MetS was associated with CHD (multi-adjusted OR range 1.66–1.72, p < 0.05). MetS affects over one-third of patients with first-ever ischemic stroke. MetS is associated with an increased likelihood of CHD in stroke patients. |
| first_indexed | 2024-04-12T08:14:49Z |
| format | Article |
| id | doaj.art-c4259d5ebe2d4eeba266458475d7505a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T08:14:49Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-c4259d5ebe2d4eeba266458475d7505a2022-12-22T03:40:49ZengNature PortfolioScientific Reports2045-23222022-07-011211910.1038/s41598-022-17369-8Metabolic syndrome in patients with first-ever ischemic stroke: prevalence and association with coronary heart diseaseYajun Liang0Zhongrui Yan1Yanlei Hao2Qiqi Wang3Zuoji Zhang4Rui She5Peng Wang6Yifeng Du7Joseph TF Lau8Joost Dekker9Bo Bai10Chengxuan Qiu11Aging Research Center & Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet-Stockholm UniversityDepartment of Neurology, Jining No. 1 People’s HospitalThe Affiliated Hospital of Jining Medical UniversityOffice of Epidemiology, Chinese Center for Disease Control and PreventionJining Medical UniversityJC School of Public Health and Primary Care, The Chinese University of Hong KongDepartment of Neurology, Jining No. 1 People’s HospitalDepartment of Neurology, Shandong Provincial Hospital Affiliated to Shandong UniversityJC School of Public Health and Primary Care, The Chinese University of Hong KongDepartment of Psychiatry and Department of Rehabilitation Medicine, Amsterdam University Medical CentresJining Medical UniversityAging Research Center & Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet-Stockholm UniversityAbstract The metabolic syndrome (MetS) has been well linked with coronary heart disease (CHD) in the general population, but studies have rarely explored their association among patients with stroke. We examine prevalence of MetS and its association with CHD in patients with first-ever ischemic stroke. This hospital-based study included 1851 patients with first-ever ischemic stroke (mean age 61.2 years, 36.5% women) who were hospitalized into two university hospitals in Shandong, China (January 2016–February 2017). Data were collected through interviews, physical examinations, and laboratory tests. MetS was defined following the National Cholesterol Education Program (NCEP) criteria, the International Diabetes Federation (IDF) criteria, and the Chinese Diabetes Society (CDS) criteria. CHD was defined following clinical criteria. Data were analyzed using binary logistic regression models. The overall prevalence of MetS was 33.4% by NECP criteria, 47.2% by IDF criteria, and 32.5% by CDS criteria, with the prevalence being decreased with age and higher in women than in men (p < 0.05). High blood pressure, high triglycerides, and low HDL-C were significantly associated with CHD (multi-adjusted odds ratio [OR] range 1.27–1.38, p < 0.05). The multi-adjusted OR of CHD associated with MetS defined by the NECP criteria, IDF criteria, and CDS criteria (vs. no MetS) was 1.27 (95% confidence interval 1.03–1.57), 1.44 (1.18–1.76), and 1.27 (1.03–1.57), respectively. In addition, having 1–2 abnormal components (vs. none) of MetS was associated with CHD (multi-adjusted OR range 1.66–1.72, p < 0.05). MetS affects over one-third of patients with first-ever ischemic stroke. MetS is associated with an increased likelihood of CHD in stroke patients.https://doi.org/10.1038/s41598-022-17369-8 |
| spellingShingle | Yajun Liang Zhongrui Yan Yanlei Hao Qiqi Wang Zuoji Zhang Rui She Peng Wang Yifeng Du Joseph TF Lau Joost Dekker Bo Bai Chengxuan Qiu Metabolic syndrome in patients with first-ever ischemic stroke: prevalence and association with coronary heart disease Scientific Reports |
| title | Metabolic syndrome in patients with first-ever ischemic stroke: prevalence and association with coronary heart disease |
| title_full | Metabolic syndrome in patients with first-ever ischemic stroke: prevalence and association with coronary heart disease |
| title_fullStr | Metabolic syndrome in patients with first-ever ischemic stroke: prevalence and association with coronary heart disease |
| title_full_unstemmed | Metabolic syndrome in patients with first-ever ischemic stroke: prevalence and association with coronary heart disease |
| title_short | Metabolic syndrome in patients with first-ever ischemic stroke: prevalence and association with coronary heart disease |
| title_sort | metabolic syndrome in patients with first ever ischemic stroke prevalence and association with coronary heart disease |
| url | https://doi.org/10.1038/s41598-022-17369-8 |
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