Disruption of Methionine Metabolism in Drosophila melanogaster Impacts Histone Methylation and Results in Loss of Viability

Disruption of Methionine Metabolism in Drosophila melanogaster Impacts Histone Methylation and Results in Loss of Viability

Histone methylation levels, which are determined by the action of both histone demethylases and methyltransferases, impact multiple biological processes by affecting gene expression activity. Methionine metabolism generates the major methyl donor S-adenosylmethionine (SAM) for histone methylation. T...

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Bibliographic Details
Main Authors: Mengying Liu, Valerie L. Barnes, Lori A. Pile
Format: Article
Language:English
Published: Oxford University Press 2016-01-01
Series:G3: Genes, Genomes, Genetics
Subjects:
methionine metabolism
histone methyltransferase
histone demethylase
Drosophila
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.115.024273

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