Propagation and Maintenance of Cancer Stem Cells: A Major Influence of the Long Non-Coding RNA <i>H19</i>
Cancer stem cells (CSCs) represent a rare population of tumor cells that exhibit stem cell properties with the abilities of self-renewal and differentiation. These cells are now widely accepted to be responsible for tumor initiation, development, resistance to conventional therapies, and recurrence....
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/12/2613 |
| _version_ | 1797545613883080704 |
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| author | Clément Lecerf Evodie Peperstraete Xuefen Le Bourhis Eric Adriaenssens |
| author_facet | Clément Lecerf Evodie Peperstraete Xuefen Le Bourhis Eric Adriaenssens |
| author_sort | Clément Lecerf |
| collection | DOAJ |
| description | Cancer stem cells (CSCs) represent a rare population of tumor cells that exhibit stem cell properties with the abilities of self-renewal and differentiation. These cells are now widely accepted to be responsible for tumor initiation, development, resistance to conventional therapies, and recurrence. Thus, a better understanding of the molecular mechanisms involved in the control of CSCs is essential to improve patient management in terms of diagnostics and therapies. CSCs are regulated by signals of the tumor microenvironment as well as intrinsic genetic and epigenetic modulators. <i>H19</i>, the first identified lncRNA is involved in the development and progression of many different cancer types. Recently, <i>H19</i> has been demonstrated to be implicated in the regulation of CSCs in different types of cancers. The aim of this review is to provide an overview of the role and mechanisms of action of <i>H19</i> in the regulation of CSCs. We summarize how <i>H19</i> may regulate CSC division and cancer cell reprogramming, thus affecting metastasis and drug resistance. We also discuss the potential clinical implications of <i>H19</i>. |
| first_indexed | 2024-03-10T14:18:47Z |
| format | Article |
| id | doaj.art-c42886fcc05d40ba930de228b1542d9b |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T14:18:47Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-c42886fcc05d40ba930de228b1542d9b2023-11-20T23:36:44ZengMDPI AGCells2073-44092020-12-01912261310.3390/cells9122613Propagation and Maintenance of Cancer Stem Cells: A Major Influence of the Long Non-Coding RNA <i>H19</i>Clément Lecerf0Evodie Peperstraete1Xuefen Le Bourhis2Eric Adriaenssens3Univ. Lille, CNRS, INSERM, CHU Lille, UMR 9020 – UMR 1277 – Canther – Cancer Heterogeneity, Plasticity and Resistance to Therapies, F-59000 Lille, FranceUniv. Lille, CNRS, INSERM, CHU Lille, UMR 9020 – UMR 1277 – Canther – Cancer Heterogeneity, Plasticity and Resistance to Therapies, F-59000 Lille, FranceUniv. Lille, CNRS, INSERM, CHU Lille, UMR 9020 – UMR 1277 – Canther – Cancer Heterogeneity, Plasticity and Resistance to Therapies, F-59000 Lille, FranceUniv. Lille, CNRS, INSERM, CHU Lille, UMR 9020 – UMR 1277 – Canther – Cancer Heterogeneity, Plasticity and Resistance to Therapies, F-59000 Lille, FranceCancer stem cells (CSCs) represent a rare population of tumor cells that exhibit stem cell properties with the abilities of self-renewal and differentiation. These cells are now widely accepted to be responsible for tumor initiation, development, resistance to conventional therapies, and recurrence. Thus, a better understanding of the molecular mechanisms involved in the control of CSCs is essential to improve patient management in terms of diagnostics and therapies. CSCs are regulated by signals of the tumor microenvironment as well as intrinsic genetic and epigenetic modulators. <i>H19</i>, the first identified lncRNA is involved in the development and progression of many different cancer types. Recently, <i>H19</i> has been demonstrated to be implicated in the regulation of CSCs in different types of cancers. The aim of this review is to provide an overview of the role and mechanisms of action of <i>H19</i> in the regulation of CSCs. We summarize how <i>H19</i> may regulate CSC division and cancer cell reprogramming, thus affecting metastasis and drug resistance. We also discuss the potential clinical implications of <i>H19</i>.https://www.mdpi.com/2073-4409/9/12/2613lncRNA<i>H19</i>non-coding RNAcancer stem cellstumorigenicityreprogramming factors |
| spellingShingle | Clément Lecerf Evodie Peperstraete Xuefen Le Bourhis Eric Adriaenssens Propagation and Maintenance of Cancer Stem Cells: A Major Influence of the Long Non-Coding RNA <i>H19</i> Cells lncRNA <i>H19</i> non-coding RNA cancer stem cells tumorigenicity reprogramming factors |
| title | Propagation and Maintenance of Cancer Stem Cells: A Major Influence of the Long Non-Coding RNA <i>H19</i> |
| title_full | Propagation and Maintenance of Cancer Stem Cells: A Major Influence of the Long Non-Coding RNA <i>H19</i> |
| title_fullStr | Propagation and Maintenance of Cancer Stem Cells: A Major Influence of the Long Non-Coding RNA <i>H19</i> |
| title_full_unstemmed | Propagation and Maintenance of Cancer Stem Cells: A Major Influence of the Long Non-Coding RNA <i>H19</i> |
| title_short | Propagation and Maintenance of Cancer Stem Cells: A Major Influence of the Long Non-Coding RNA <i>H19</i> |
| title_sort | propagation and maintenance of cancer stem cells a major influence of the long non coding rna i h19 i |
| topic | lncRNA <i>H19</i> non-coding RNA cancer stem cells tumorigenicity reprogramming factors |
| url | https://www.mdpi.com/2073-4409/9/12/2613 |
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