Territrem and Butyrolactone Derivatives from a Marine-Derived Fungus Aspergillus Terreus
Seventeen lactones including eight territrem derivatives (1–8) and nine butyrolactone derivatives (9–17) were isolated from a marine-derived fungus Aspergillus terreus SCSGAF0162 under solid-state fermentation of rice. Compounds 1–3 and 9–10 were new, and their structures were elucidated by spectros...
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-12-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/12/12/6113 |
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| author | Xu-Hua Nong Yi-Fei Wang Xiao-Yong Zhang Mu-Ping Zhou Xin-Ya Xu Shu-Hua Qi |
| author_facet | Xu-Hua Nong Yi-Fei Wang Xiao-Yong Zhang Mu-Ping Zhou Xin-Ya Xu Shu-Hua Qi |
| author_sort | Xu-Hua Nong |
| collection | DOAJ |
| description | Seventeen lactones including eight territrem derivatives (1–8) and nine butyrolactone derivatives (9–17) were isolated from a marine-derived fungus Aspergillus terreus SCSGAF0162 under solid-state fermentation of rice. Compounds 1–3 and 9–10 were new, and their structures were elucidated by spectroscopic analysis. The acetylcholinesterase inhibitory activity and antiviral activity of compounds 1–17 were evaluated. Among them, compounds 1 and 2 showed strong inhibitory activity against acetylcholinesterase with IC50 values of 4.2 ± 0.6, 4.5 ± 0.6 nM, respectively. This is the first time it has been reported that 3, 6, 10, 12 had evident antiviral activity towards HSV-1 with IC50 values of 16.4 ± 0.6, 6.34 ± 0.4, 21.8 ± 0.8 and 28.9 ± 0.8 μg·mL−1, respectively. Antifouling bioassay tests showed that compounds 1, 11, 12, 15 had potent antifouling activity with EC50 values of 12.9 ± 0.5, 22.1 ± 0.8, 7.4 ± 0.6, 16.1 ± 0.6 μg·mL−1 toward barnacle Balanus amphitrite larvae, respectively. |
| first_indexed | 2024-04-11T12:09:57Z |
| format | Article |
| id | doaj.art-c42be1b8cb624d919b915590b91ed3a5 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T12:09:57Z |
| publishDate | 2014-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-c42be1b8cb624d919b915590b91ed3a52022-12-22T04:24:38ZengMDPI AGMarine Drugs1660-33972014-12-0112126113612410.3390/md12126113md12126113Territrem and Butyrolactone Derivatives from a Marine-Derived Fungus Aspergillus TerreusXu-Hua Nong0Yi-Fei Wang1Xiao-Yong Zhang2Mu-Ping Zhou3Xin-Ya Xu4Shu-Hua Qi5CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, 510301 Guangdong, ChinaJinan University, 601 West Huangpu Road, Guangzhou, 510632 Guangdong, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, 510301 Guangdong, ChinaJinan University, 601 West Huangpu Road, Guangzhou, 510632 Guangdong, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, 510301 Guangdong, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, 510301 Guangdong, ChinaSeventeen lactones including eight territrem derivatives (1–8) and nine butyrolactone derivatives (9–17) were isolated from a marine-derived fungus Aspergillus terreus SCSGAF0162 under solid-state fermentation of rice. Compounds 1–3 and 9–10 were new, and their structures were elucidated by spectroscopic analysis. The acetylcholinesterase inhibitory activity and antiviral activity of compounds 1–17 were evaluated. Among them, compounds 1 and 2 showed strong inhibitory activity against acetylcholinesterase with IC50 values of 4.2 ± 0.6, 4.5 ± 0.6 nM, respectively. This is the first time it has been reported that 3, 6, 10, 12 had evident antiviral activity towards HSV-1 with IC50 values of 16.4 ± 0.6, 6.34 ± 0.4, 21.8 ± 0.8 and 28.9 ± 0.8 μg·mL−1, respectively. Antifouling bioassay tests showed that compounds 1, 11, 12, 15 had potent antifouling activity with EC50 values of 12.9 ± 0.5, 22.1 ± 0.8, 7.4 ± 0.6, 16.1 ± 0.6 μg·mL−1 toward barnacle Balanus amphitrite larvae, respectively.http://www.mdpi.com/1660-3397/12/12/6113Aspergillus terreusanti-acetylcholinesteraseanti-HSV-1antifoulingbutyrolactone derivativeterritrem derivative |
| spellingShingle | Xu-Hua Nong Yi-Fei Wang Xiao-Yong Zhang Mu-Ping Zhou Xin-Ya Xu Shu-Hua Qi Territrem and Butyrolactone Derivatives from a Marine-Derived Fungus Aspergillus Terreus Marine Drugs Aspergillus terreus anti-acetylcholinesterase anti-HSV-1 antifouling butyrolactone derivative territrem derivative |
| title | Territrem and Butyrolactone Derivatives from a Marine-Derived Fungus Aspergillus Terreus |
| title_full | Territrem and Butyrolactone Derivatives from a Marine-Derived Fungus Aspergillus Terreus |
| title_fullStr | Territrem and Butyrolactone Derivatives from a Marine-Derived Fungus Aspergillus Terreus |
| title_full_unstemmed | Territrem and Butyrolactone Derivatives from a Marine-Derived Fungus Aspergillus Terreus |
| title_short | Territrem and Butyrolactone Derivatives from a Marine-Derived Fungus Aspergillus Terreus |
| title_sort | territrem and butyrolactone derivatives from a marine derived fungus aspergillus terreus |
| topic | Aspergillus terreus anti-acetylcholinesterase anti-HSV-1 antifouling butyrolactone derivative territrem derivative |
| url | http://www.mdpi.com/1660-3397/12/12/6113 |
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