Exploiting Urazole’s Acidity for Fabrication of Hydrogels and Ion-Exchange Materials
In this study, the acidity of urazole (pKa 5–6) was exploited to fabricate a hydrogel in two simple and scalable steps. Commercially available poly(hexamethylene)diisocyanate was used as a precursor to synthesize an urazole containing gel. The formation of urazole was confirmed by FT-IR and <sup&...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/7/4/261 |
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| author | Saltuk B. Hanay Ali Fallah Efsun Senturk Zeliha Yetim Ferdows Afghah Hulya Yilmaz Mustafa Culha Bahattin Koc Ali Zarrabi Rajender S. Varma |
| author_facet | Saltuk B. Hanay Ali Fallah Efsun Senturk Zeliha Yetim Ferdows Afghah Hulya Yilmaz Mustafa Culha Bahattin Koc Ali Zarrabi Rajender S. Varma |
| author_sort | Saltuk B. Hanay |
| collection | DOAJ |
| description | In this study, the acidity of urazole (pKa 5–6) was exploited to fabricate a hydrogel in two simple and scalable steps. Commercially available poly(hexamethylene)diisocyanate was used as a precursor to synthesize an urazole containing gel. The formation of urazole was confirmed by FT-IR and <sup>1</sup>H-NMR spectroscopy. The hydrogel was characterized by microscopy imaging as well as spectroscopic and thermo-gravimetric analyses. Mechanical analysis and cell viability tests were performed for its initial biocompatibility evaluation. The prepared hydrogel is a highly porous hydrogel with a Young’s modulus of 0.91 MPa, has a swelling ratio of 87%, and is capable of exchanging ions in a medium. Finally, a general strategy was demonstrated to embed urazole groups directly into a crosslinked material. |
| first_indexed | 2024-03-10T04:03:39Z |
| format | Article |
| id | doaj.art-c42d7249c8374c0088c7c271533cbc6a |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-10T04:03:39Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-c42d7249c8374c0088c7c271533cbc6a2023-11-23T08:28:43ZengMDPI AGGels2310-28612021-12-017426110.3390/gels7040261Exploiting Urazole’s Acidity for Fabrication of Hydrogels and Ion-Exchange MaterialsSaltuk B. Hanay0Ali Fallah1Efsun Senturk2Zeliha Yetim3Ferdows Afghah4Hulya Yilmaz5Mustafa Culha6Bahattin Koc7Ali Zarrabi8Rajender S. Varma9Faculty of Engineering and Natural Sciences (FENS), Sabanci University, Istanbul 34956, TurkeyFaculty of Engineering and Natural Sciences (FENS), Sabanci University, Istanbul 34956, TurkeyFaculty of Engineering and Natural Sciences (FENS), Sabanci University, Istanbul 34956, TurkeyDepartment of Histology and Embryology, Faculty of Medicine, Ataturk University, Erzurum 25240, TurkeyFaculty of Engineering and Natural Sciences (FENS), Sabanci University, Istanbul 34956, TurkeySabancı University Nanotechnology Research and Application Center—SUNUM, Istanbul 34956, TurkeySabancı University Nanotechnology Research and Application Center—SUNUM, Istanbul 34956, TurkeyFaculty of Engineering and Natural Sciences (FENS), Sabanci University, Istanbul 34956, TurkeyDepartment of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, Istanbul 34396, TurkeyRegional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacký University in Olomouc, 78371 Olomouc, Czech RepublicIn this study, the acidity of urazole (pKa 5–6) was exploited to fabricate a hydrogel in two simple and scalable steps. Commercially available poly(hexamethylene)diisocyanate was used as a precursor to synthesize an urazole containing gel. The formation of urazole was confirmed by FT-IR and <sup>1</sup>H-NMR spectroscopy. The hydrogel was characterized by microscopy imaging as well as spectroscopic and thermo-gravimetric analyses. Mechanical analysis and cell viability tests were performed for its initial biocompatibility evaluation. The prepared hydrogel is a highly porous hydrogel with a Young’s modulus of 0.91 MPa, has a swelling ratio of 87%, and is capable of exchanging ions in a medium. Finally, a general strategy was demonstrated to embed urazole groups directly into a crosslinked material.https://www.mdpi.com/2310-2861/7/4/261hydrogelsurazoleion-exchangeporous gelsbiomaterials |
| spellingShingle | Saltuk B. Hanay Ali Fallah Efsun Senturk Zeliha Yetim Ferdows Afghah Hulya Yilmaz Mustafa Culha Bahattin Koc Ali Zarrabi Rajender S. Varma Exploiting Urazole’s Acidity for Fabrication of Hydrogels and Ion-Exchange Materials Gels hydrogels urazole ion-exchange porous gels biomaterials |
| title | Exploiting Urazole’s Acidity for Fabrication of Hydrogels and Ion-Exchange Materials |
| title_full | Exploiting Urazole’s Acidity for Fabrication of Hydrogels and Ion-Exchange Materials |
| title_fullStr | Exploiting Urazole’s Acidity for Fabrication of Hydrogels and Ion-Exchange Materials |
| title_full_unstemmed | Exploiting Urazole’s Acidity for Fabrication of Hydrogels and Ion-Exchange Materials |
| title_short | Exploiting Urazole’s Acidity for Fabrication of Hydrogels and Ion-Exchange Materials |
| title_sort | exploiting urazole s acidity for fabrication of hydrogels and ion exchange materials |
| topic | hydrogels urazole ion-exchange porous gels biomaterials |
| url | https://www.mdpi.com/2310-2861/7/4/261 |
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