Increased levels of a subset of angiogenesis-related plasma proteins in essential thrombocythemia
Background: Increased local angiogenesis is important for the growth and dissemination of cancer. The myeloproliferative neoplasm essential thrombocythemia (ET) is known to involve increased bone marrow angiogenesis. Blood levels of several angiogenesis-related proteins are increased in different ty...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Upsala Medical Society
2023-03-01
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| Series: | Upsala Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://ujms.net/index.php/ujms/article/view/9194/15472 |
| _version_ | 1797699885973110784 |
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| author | Sofia Vikman Anders Larsson Måns Thulin Torbjörn Karlsson |
| author_facet | Sofia Vikman Anders Larsson Måns Thulin Torbjörn Karlsson |
| author_sort | Sofia Vikman |
| collection | DOAJ |
| description | Background: Increased local angiogenesis is important for the growth and dissemination of cancer. The myeloproliferative neoplasm essential thrombocythemia (ET) is known to involve increased bone marrow angiogenesis. Blood levels of several angiogenesis-related proteins are increased in different types of cancer. The aim of this study was to investigate whether a subset of such proteins was elevated in treatment-naïve ET patients. Methods: Blood plasma from 41 ET patients and 43 healthy aged-matched controls was analyzed for eight different angiogenesis-related proteins. Results: The ET cohort displayed a more homogenous expression pattern of these proteins compared with controls. Five of the eight proteins were significantly increased in ET patients. Conclusion: Increased plasma levels of matrix metallopeptidase 9 (MMP9) and endostatin have not previously been reported in ET. In our patients, MMP9 levels correlated positively with Janus kinase 2 (JAK2) V617F allele burden and leukocyte count. |
| first_indexed | 2024-03-12T04:14:20Z |
| format | Article |
| id | doaj.art-c42ecd32de804e23bab4603479e09b35 |
| institution | Directory Open Access Journal |
| issn | 0300-9734 2000-1967 |
| language | English |
| last_indexed | 2024-03-12T04:14:20Z |
| publishDate | 2023-03-01 |
| publisher | Upsala Medical Society |
| record_format | Article |
| series | Upsala Journal of Medical Sciences |
| spelling | doaj.art-c42ecd32de804e23bab4603479e09b352023-09-03T10:46:04ZengUpsala Medical SocietyUpsala Journal of Medical Sciences0300-97342000-19672023-03-011281610.48101/ujms.v128.91949194Increased levels of a subset of angiogenesis-related plasma proteins in essential thrombocythemiaSofia Vikman0Anders Larsson1Måns Thulin2Torbjörn Karlsson3Department of Medical Sciences, Uppsala University, Uppsala, SwedenDepartment of Medical Sciences, Uppsala University, Uppsala, SwedenDepartment of Mathematics, Uppsala University, Uppsala, SwedenDepartment of Medical Sciences, Uppsala University, Uppsala, SwedenBackground: Increased local angiogenesis is important for the growth and dissemination of cancer. The myeloproliferative neoplasm essential thrombocythemia (ET) is known to involve increased bone marrow angiogenesis. Blood levels of several angiogenesis-related proteins are increased in different types of cancer. The aim of this study was to investigate whether a subset of such proteins was elevated in treatment-naïve ET patients. Methods: Blood plasma from 41 ET patients and 43 healthy aged-matched controls was analyzed for eight different angiogenesis-related proteins. Results: The ET cohort displayed a more homogenous expression pattern of these proteins compared with controls. Five of the eight proteins were significantly increased in ET patients. Conclusion: Increased plasma levels of matrix metallopeptidase 9 (MMP9) and endostatin have not previously been reported in ET. In our patients, MMP9 levels correlated positively with Janus kinase 2 (JAK2) V617F allele burden and leukocyte count.https://ujms.net/index.php/ujms/article/view/9194/15472essential thrombocythemiaangiogenesisextracellular matrixmatrix metallopeptidase 9endostatin |
| spellingShingle | Sofia Vikman Anders Larsson Måns Thulin Torbjörn Karlsson Increased levels of a subset of angiogenesis-related plasma proteins in essential thrombocythemia Upsala Journal of Medical Sciences essential thrombocythemia angiogenesis extracellular matrix matrix metallopeptidase 9 endostatin |
| title | Increased levels of a subset of angiogenesis-related plasma proteins in essential thrombocythemia |
| title_full | Increased levels of a subset of angiogenesis-related plasma proteins in essential thrombocythemia |
| title_fullStr | Increased levels of a subset of angiogenesis-related plasma proteins in essential thrombocythemia |
| title_full_unstemmed | Increased levels of a subset of angiogenesis-related plasma proteins in essential thrombocythemia |
| title_short | Increased levels of a subset of angiogenesis-related plasma proteins in essential thrombocythemia |
| title_sort | increased levels of a subset of angiogenesis related plasma proteins in essential thrombocythemia |
| topic | essential thrombocythemia angiogenesis extracellular matrix matrix metallopeptidase 9 endostatin |
| url | https://ujms.net/index.php/ujms/article/view/9194/15472 |
| work_keys_str_mv | AT sofiavikman increasedlevelsofasubsetofangiogenesisrelatedplasmaproteinsinessentialthrombocythemia AT anderslarsson increasedlevelsofasubsetofangiogenesisrelatedplasmaproteinsinessentialthrombocythemia AT mansthulin increasedlevelsofasubsetofangiogenesisrelatedplasmaproteinsinessentialthrombocythemia AT torbjornkarlsson increasedlevelsofasubsetofangiogenesisrelatedplasmaproteinsinessentialthrombocythemia |