microRNAs: Novel regulators of the TGF-β pathway in pancreatic ductal adenocarcinoma

microRNAs: Novel regulators of the TGF-β pathway in pancreatic ductal adenocarcinoma

We identified that transforming growth factor-β (TGF-β) induces long non-coding RNA (lncRNA) MIR100HG along with its host microRNAs (miRNAs) miR-100 and miR-125b, to regulate its response in pancreatic ductal adenocarcinoma (PDAC). Importantly let-7a, despite originating from MIR100HG, remains uncha...

Full description

Bibliographic Details
Main Authors: Silvia Ottaviani, Leandro Castellano
Format: Article
Language:English
Published: Taylor & Francis Group 2018-11-01
Series:Molecular & Cellular Oncology
Subjects:
tgf-β
micrornas
mir-100
mir-125b
let-7
emt
csc
stemness
metastasis
pdac
Online Access:http://dx.doi.org/10.1080/23723556.2018.1499066
Description
Summary:We identified that transforming growth factor-β (TGF-β) induces long non-coding RNA (lncRNA) MIR100HG along with its host microRNAs (miRNAs) miR-100 and miR-125b, to regulate its response in pancreatic ductal adenocarcinoma (PDAC). Importantly let-7a, despite originating from MIR100HG, remains unchanged because post-transcriptionally repressed by lin-28 homolog B (LIN28B). A novel method for global miRNA-target discovery identified that miR-100/125b regulates crucial PDAC pathways.
ISSN:2372-3556

Similar Items