Polysaccharides from Panax ginseng C. A. Meyer alleviated DSS-induced IBD by inhibiting JAK2/STAT1/NLPR3 inflammasome signalling pathway in mice
Panax ginseng polysaccharides (GPS) are isolated from Panax ginseng C. A. Meyer, which has many pharmacological activities. However, although the protective effect of GPS on inflammatory bowel disease (IBD) has been characterized, its mechanism has not yet been fully elucidated. In the present study...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-04-01
|
| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622000834 |
| _version_ | 1818317806472527872 |
|---|---|
| author | Yuangeng Li Ping Yu Wenwen Fu Jing Wang Yue Ma Yi Wu Heming Cui Wenjun Zhao Fuyuan Zhang Xiaofeng Yu Dayun Sui Huali Xu |
| author_facet | Yuangeng Li Ping Yu Wenwen Fu Jing Wang Yue Ma Yi Wu Heming Cui Wenjun Zhao Fuyuan Zhang Xiaofeng Yu Dayun Sui Huali Xu |
| author_sort | Yuangeng Li |
| collection | DOAJ |
| description | Panax ginseng polysaccharides (GPS) are isolated from Panax ginseng C. A. Meyer, which has many pharmacological activities. However, although the protective effect of GPS on inflammatory bowel disease (IBD) has been characterized, its mechanism has not yet been fully elucidated. In the present study, we clarified it effect on IBD in mice and studied the mechanism of reducing inflammation. IBD model was established in mice by administrating dextran sulfate sodium (DSS) in drinking water for 7 days. Our results showed that GPS treatment significantly relieved disease activity index, colon length shortening and pathological changes in colonic tissue. Furthermore, GPS treatment significantly reduced oxidative stress and inflammatory cytokines in the colonic tissue via inhibiting JAK2/STAT1/NLRP3 inflammasome signalling pathway. In conclusion, these results demonstrated that GPS could attenuate inflammatory response via inhibiting JAK2/STAT1/NLPR3 inflammasome signalling pathway. Hence, GPS may be a potential natural medicine to inhibit JAK2/STAT1/NLRP3 inflammasome signalling pathway and reduce inflammation in IBD. |
| first_indexed | 2024-12-13T09:43:11Z |
| format | Article |
| id | doaj.art-c43107480e98459caff69799116a32f4 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-13T09:43:11Z |
| publishDate | 2022-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-c43107480e98459caff69799116a32f42022-12-21T23:52:08ZengElsevierJournal of Functional Foods1756-46462022-04-0191105013Polysaccharides from Panax ginseng C. A. Meyer alleviated DSS-induced IBD by inhibiting JAK2/STAT1/NLPR3 inflammasome signalling pathway in miceYuangeng Li0Ping Yu1Wenwen Fu2Jing Wang3Yue Ma4Yi Wu5Heming Cui6Wenjun Zhao7Fuyuan Zhang8Xiaofeng Yu9Dayun Sui10Huali Xu11Department of Pharmacology, School of Pharmaceutical Sciences, Jilin University, Changchun, ChinaDepartment of Pharmacology, School of Pharmaceutical Sciences, Jilin University, Changchun, ChinaDepartment of Pharmacology, School of Pharmaceutical Sciences, Jilin University, Changchun, ChinaDepartment of Pharmacology, School of Pharmaceutical Sciences, Jilin University, Changchun, ChinaDepartment of Pharmacology, School of Pharmaceutical Sciences, Jilin University, Changchun, ChinaDepartment of Pharmacology, School of Pharmaceutical Sciences, Jilin University, Changchun, ChinaDepartment of Pharmacology, School of Pharmaceutical Sciences, Jilin University, Changchun, ChinaDepartment of Pharmacology, School of Pharmaceutical Sciences, Jilin University, Changchun, ChinaDepartment of Pharmacology, School of Pharmaceutical Sciences, Jilin University, Changchun, ChinaDepartment of Pharmacology, School of Pharmaceutical Sciences, Jilin University, Changchun, ChinaDepartment of Pharmacology, School of Pharmaceutical Sciences, Jilin University, Changchun, ChinaCorresponding author at: Department of Pharmacology, School of Pharmaceutical Sciences, Jilin University, No.1266, Fujin Road, Changchun, China.; Department of Pharmacology, School of Pharmaceutical Sciences, Jilin University, Changchun, ChinaPanax ginseng polysaccharides (GPS) are isolated from Panax ginseng C. A. Meyer, which has many pharmacological activities. However, although the protective effect of GPS on inflammatory bowel disease (IBD) has been characterized, its mechanism has not yet been fully elucidated. In the present study, we clarified it effect on IBD in mice and studied the mechanism of reducing inflammation. IBD model was established in mice by administrating dextran sulfate sodium (DSS) in drinking water for 7 days. Our results showed that GPS treatment significantly relieved disease activity index, colon length shortening and pathological changes in colonic tissue. Furthermore, GPS treatment significantly reduced oxidative stress and inflammatory cytokines in the colonic tissue via inhibiting JAK2/STAT1/NLRP3 inflammasome signalling pathway. In conclusion, these results demonstrated that GPS could attenuate inflammatory response via inhibiting JAK2/STAT1/NLPR3 inflammasome signalling pathway. Hence, GPS may be a potential natural medicine to inhibit JAK2/STAT1/NLRP3 inflammasome signalling pathway and reduce inflammation in IBD.http://www.sciencedirect.com/science/article/pii/S1756464622000834Panax ginseng polysaccharidesIBDNLRP3 inflammasomeJAK2/STAT1 signalling pathway |
| spellingShingle | Yuangeng Li Ping Yu Wenwen Fu Jing Wang Yue Ma Yi Wu Heming Cui Wenjun Zhao Fuyuan Zhang Xiaofeng Yu Dayun Sui Huali Xu Polysaccharides from Panax ginseng C. A. Meyer alleviated DSS-induced IBD by inhibiting JAK2/STAT1/NLPR3 inflammasome signalling pathway in mice Journal of Functional Foods Panax ginseng polysaccharides IBD NLRP3 inflammasome JAK2/STAT1 signalling pathway |
| title | Polysaccharides from Panax ginseng C. A. Meyer alleviated DSS-induced IBD by inhibiting JAK2/STAT1/NLPR3 inflammasome signalling pathway in mice |
| title_full | Polysaccharides from Panax ginseng C. A. Meyer alleviated DSS-induced IBD by inhibiting JAK2/STAT1/NLPR3 inflammasome signalling pathway in mice |
| title_fullStr | Polysaccharides from Panax ginseng C. A. Meyer alleviated DSS-induced IBD by inhibiting JAK2/STAT1/NLPR3 inflammasome signalling pathway in mice |
| title_full_unstemmed | Polysaccharides from Panax ginseng C. A. Meyer alleviated DSS-induced IBD by inhibiting JAK2/STAT1/NLPR3 inflammasome signalling pathway in mice |
| title_short | Polysaccharides from Panax ginseng C. A. Meyer alleviated DSS-induced IBD by inhibiting JAK2/STAT1/NLPR3 inflammasome signalling pathway in mice |
| title_sort | polysaccharides from panax ginseng c a meyer alleviated dss induced ibd by inhibiting jak2 stat1 nlpr3 inflammasome signalling pathway in mice |
| topic | Panax ginseng polysaccharides IBD NLRP3 inflammasome JAK2/STAT1 signalling pathway |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622000834 |
| work_keys_str_mv | AT yuangengli polysaccharidesfrompanaxginsengcameyeralleviateddssinducedibdbyinhibitingjak2stat1nlpr3inflammasomesignallingpathwayinmice AT pingyu polysaccharidesfrompanaxginsengcameyeralleviateddssinducedibdbyinhibitingjak2stat1nlpr3inflammasomesignallingpathwayinmice AT wenwenfu polysaccharidesfrompanaxginsengcameyeralleviateddssinducedibdbyinhibitingjak2stat1nlpr3inflammasomesignallingpathwayinmice AT jingwang polysaccharidesfrompanaxginsengcameyeralleviateddssinducedibdbyinhibitingjak2stat1nlpr3inflammasomesignallingpathwayinmice AT yuema polysaccharidesfrompanaxginsengcameyeralleviateddssinducedibdbyinhibitingjak2stat1nlpr3inflammasomesignallingpathwayinmice AT yiwu polysaccharidesfrompanaxginsengcameyeralleviateddssinducedibdbyinhibitingjak2stat1nlpr3inflammasomesignallingpathwayinmice AT hemingcui polysaccharidesfrompanaxginsengcameyeralleviateddssinducedibdbyinhibitingjak2stat1nlpr3inflammasomesignallingpathwayinmice AT wenjunzhao polysaccharidesfrompanaxginsengcameyeralleviateddssinducedibdbyinhibitingjak2stat1nlpr3inflammasomesignallingpathwayinmice AT fuyuanzhang polysaccharidesfrompanaxginsengcameyeralleviateddssinducedibdbyinhibitingjak2stat1nlpr3inflammasomesignallingpathwayinmice AT xiaofengyu polysaccharidesfrompanaxginsengcameyeralleviateddssinducedibdbyinhibitingjak2stat1nlpr3inflammasomesignallingpathwayinmice AT dayunsui polysaccharidesfrompanaxginsengcameyeralleviateddssinducedibdbyinhibitingjak2stat1nlpr3inflammasomesignallingpathwayinmice AT hualixu polysaccharidesfrompanaxginsengcameyeralleviateddssinducedibdbyinhibitingjak2stat1nlpr3inflammasomesignallingpathwayinmice |