Summary of Known Genetic and Epigenetic Modification Contributed to Hypertension
Hypertension is a multifactorial disease due to a complex interaction among genetic, epigenetic, and environmental factors. Characterized by raised blood pressure (BP), it is responsible for more than 7 million deaths per annum by acting as a leading preventable risk factor for cardiovascular diseas...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2023-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2023/5872362 |
| _version_ | 1797825703487471616 |
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| author | Tiar Masykuroh Pratamawati Idrus Alwi null Asmarinah |
| author_facet | Tiar Masykuroh Pratamawati Idrus Alwi null Asmarinah |
| author_sort | Tiar Masykuroh Pratamawati |
| collection | DOAJ |
| description | Hypertension is a multifactorial disease due to a complex interaction among genetic, epigenetic, and environmental factors. Characterized by raised blood pressure (BP), it is responsible for more than 7 million deaths per annum by acting as a leading preventable risk factor for cardiovascular disease. Reports suggest that genetic factors are estimated to be involved in approximately 30 to 50% of BP variation, and epigenetic marks are known to contribute to the initiation of the disease by influencing gene expression. Consequently, elucidating the genetic and epigenetic mediators associated with hypertension is essential for better discernment of its pathophysiology. By deciphering the unprecedented molecular hypertension basis, it could help to unravel an individual’s inclination towards hypertension which eventually could result in an arrangement of potential strategies for prevention and therapy. In the present review, we discuss known genetic and epigenetic drivers that contributed to the hypertension development and summarize the novel variants that have currently been identified. The effect of these molecular alterations on endothelial function was also presented. |
| first_indexed | 2024-03-13T10:57:44Z |
| format | Article |
| id | doaj.art-c431d98f65144223837ced6357089552 |
| institution | Directory Open Access Journal |
| issn | 2090-0392 |
| language | English |
| last_indexed | 2024-03-13T10:57:44Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj.art-c431d98f65144223837ced63570895522023-05-17T00:00:02ZengHindawi LimitedInternational Journal of Hypertension2090-03922023-01-01202310.1155/2023/5872362Summary of Known Genetic and Epigenetic Modification Contributed to HypertensionTiar Masykuroh Pratamawati0Idrus Alwi1null Asmarinah2Program Doctoral Biomedical ScienceDivision of CardiologyDepartment of Medical BiologyHypertension is a multifactorial disease due to a complex interaction among genetic, epigenetic, and environmental factors. Characterized by raised blood pressure (BP), it is responsible for more than 7 million deaths per annum by acting as a leading preventable risk factor for cardiovascular disease. Reports suggest that genetic factors are estimated to be involved in approximately 30 to 50% of BP variation, and epigenetic marks are known to contribute to the initiation of the disease by influencing gene expression. Consequently, elucidating the genetic and epigenetic mediators associated with hypertension is essential for better discernment of its pathophysiology. By deciphering the unprecedented molecular hypertension basis, it could help to unravel an individual’s inclination towards hypertension which eventually could result in an arrangement of potential strategies for prevention and therapy. In the present review, we discuss known genetic and epigenetic drivers that contributed to the hypertension development and summarize the novel variants that have currently been identified. The effect of these molecular alterations on endothelial function was also presented.http://dx.doi.org/10.1155/2023/5872362 |
| spellingShingle | Tiar Masykuroh Pratamawati Idrus Alwi null Asmarinah Summary of Known Genetic and Epigenetic Modification Contributed to Hypertension International Journal of Hypertension |
| title | Summary of Known Genetic and Epigenetic Modification Contributed to Hypertension |
| title_full | Summary of Known Genetic and Epigenetic Modification Contributed to Hypertension |
| title_fullStr | Summary of Known Genetic and Epigenetic Modification Contributed to Hypertension |
| title_full_unstemmed | Summary of Known Genetic and Epigenetic Modification Contributed to Hypertension |
| title_short | Summary of Known Genetic and Epigenetic Modification Contributed to Hypertension |
| title_sort | summary of known genetic and epigenetic modification contributed to hypertension |
| url | http://dx.doi.org/10.1155/2023/5872362 |
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