Frontostriatal circuitry as a target for fMRI-based neurofeedback interventions: A systematic review
Dysregulated frontostriatal circuitries are viewed as a common target for the treatment of aberrant behaviors in various psychiatric and neurological disorders. Accordingly, experimental neurofeedback paradigms have been applied to modify the frontostriatal circuitry. The human frontostriatal circui...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2022.933718/full |
| _version_ | 1817998449800380416 |
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| author | Linda Orth Johanna Meeh Ruben C. Gur Irene Neuner Irene Neuner Pegah Sarkheil |
| author_facet | Linda Orth Johanna Meeh Ruben C. Gur Irene Neuner Irene Neuner Pegah Sarkheil |
| author_sort | Linda Orth |
| collection | DOAJ |
| description | Dysregulated frontostriatal circuitries are viewed as a common target for the treatment of aberrant behaviors in various psychiatric and neurological disorders. Accordingly, experimental neurofeedback paradigms have been applied to modify the frontostriatal circuitry. The human frontostriatal circuitry is topographically and functionally organized into the “limbic,” the “associative,” and the “motor” subsystems underlying a variety of affective, cognitive, and motor functions. We conducted a systematic review of the literature regarding functional magnetic resonance imaging-based neurofeedback studies that targeted brain activations within the frontostriatal circuitry. Seventy-nine published studies were included in our survey. We assessed the efficacy of these studies in terms of imaging findings of neurofeedback intervention as well as behavioral and clinical outcomes. Furthermore, we evaluated whether the neurofeedback targets of the studies could be assigned to the identifiable frontostriatal subsystems. The majority of studies that targeted frontostriatal circuitry functions focused on the anterior cingulate cortex, the dorsolateral prefrontal cortex, and the supplementary motor area. Only a few studies (n = 14) targeted the connectivity of the frontostriatal regions. However, post-hoc analyses of connectivity changes were reported in more cases (n = 32). Neurofeedback has been frequently used to modify brain activations within the frontostriatal circuitry. Given the regulatory mechanisms within the closed loop of the frontostriatal circuitry, the connectivity-based neurofeedback paradigms should be primarily considered for modifications of this system. The anatomical and functional organization of the frontostriatal system needs to be considered in decisions pertaining to the neurofeedback targets. |
| first_indexed | 2024-04-14T02:52:50Z |
| format | Article |
| id | doaj.art-c4321e7289a54ff9905fcd5bc74d125a |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-04-14T02:52:50Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-c4321e7289a54ff9905fcd5bc74d125a2022-12-22T02:16:13ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612022-08-011610.3389/fnhum.2022.933718933718Frontostriatal circuitry as a target for fMRI-based neurofeedback interventions: A systematic reviewLinda Orth0Johanna Meeh1Ruben C. Gur2Irene Neuner3Irene Neuner4Pegah Sarkheil5Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, GermanyDepartment of Psychiatry and Psychotherapy, University of Münster, Münster, GermanyDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesDepartment of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, GermanyInstitute of Neuroscience and Medicine 4, Forschungszentrum Jülich, Jülich, GermanyDepartment of Psychiatry and Psychotherapy, University of Münster, Münster, GermanyDysregulated frontostriatal circuitries are viewed as a common target for the treatment of aberrant behaviors in various psychiatric and neurological disorders. Accordingly, experimental neurofeedback paradigms have been applied to modify the frontostriatal circuitry. The human frontostriatal circuitry is topographically and functionally organized into the “limbic,” the “associative,” and the “motor” subsystems underlying a variety of affective, cognitive, and motor functions. We conducted a systematic review of the literature regarding functional magnetic resonance imaging-based neurofeedback studies that targeted brain activations within the frontostriatal circuitry. Seventy-nine published studies were included in our survey. We assessed the efficacy of these studies in terms of imaging findings of neurofeedback intervention as well as behavioral and clinical outcomes. Furthermore, we evaluated whether the neurofeedback targets of the studies could be assigned to the identifiable frontostriatal subsystems. The majority of studies that targeted frontostriatal circuitry functions focused on the anterior cingulate cortex, the dorsolateral prefrontal cortex, and the supplementary motor area. Only a few studies (n = 14) targeted the connectivity of the frontostriatal regions. However, post-hoc analyses of connectivity changes were reported in more cases (n = 32). Neurofeedback has been frequently used to modify brain activations within the frontostriatal circuitry. Given the regulatory mechanisms within the closed loop of the frontostriatal circuitry, the connectivity-based neurofeedback paradigms should be primarily considered for modifications of this system. The anatomical and functional organization of the frontostriatal system needs to be considered in decisions pertaining to the neurofeedback targets.https://www.frontiersin.org/articles/10.3389/fnhum.2022.933718/fullneurofeedbackreal-time fMRIconnectivity neurofeedbackneuromodulationfrontostriatal circuitry |
| spellingShingle | Linda Orth Johanna Meeh Ruben C. Gur Irene Neuner Irene Neuner Pegah Sarkheil Frontostriatal circuitry as a target for fMRI-based neurofeedback interventions: A systematic review Frontiers in Human Neuroscience neurofeedback real-time fMRI connectivity neurofeedback neuromodulation frontostriatal circuitry |
| title | Frontostriatal circuitry as a target for fMRI-based neurofeedback interventions: A systematic review |
| title_full | Frontostriatal circuitry as a target for fMRI-based neurofeedback interventions: A systematic review |
| title_fullStr | Frontostriatal circuitry as a target for fMRI-based neurofeedback interventions: A systematic review |
| title_full_unstemmed | Frontostriatal circuitry as a target for fMRI-based neurofeedback interventions: A systematic review |
| title_short | Frontostriatal circuitry as a target for fMRI-based neurofeedback interventions: A systematic review |
| title_sort | frontostriatal circuitry as a target for fmri based neurofeedback interventions a systematic review |
| topic | neurofeedback real-time fMRI connectivity neurofeedback neuromodulation frontostriatal circuitry |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2022.933718/full |
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