Design and synthesis of some new benzoylthioureido phenyl derivatives targeting carbonic anhydrase enzymes

Design and synthesis of some new benzoylthioureido phenyl derivatives targeting carbonic anhydrase enzymes

The present study aimed to develop potent carbonic anhydrase inhibitors (CAIs). The design of the target compounds was based on modifying the structure of the ureido-based carbonic anhydrase inhibitor SLC-0111. Six series of a substituted benzoylthioureido core were prepared featuring different zinc...

Full description

Bibliographic Details
Main Authors: Mazin A. A. Najm, Walaa R. Mahmoud, Azza T. Taher, Safinaz E-S. Abbas, Fadi M. Awadallah, Heba Abdelrasheed Allam, Daniela Vullo, Claudiu T. Supuran
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Sulphonamides
carbonic anhydrase
SLC-0111
benzoylthioureido derivatives
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2022.2126463

Similar Items

Similar Items