Multi-category diagnostic accuracy based on logistic regression

We provide a detailed review for the statistical analysis of diagnostic accuracy in a multi-category classification task. For qualitative response variables with more than two categories, many traditional accuracy measures such as sensitivity, specificity and area under the ROC curve are no longer a...

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Main Authors: Jialiang Li, Jason P. Fine, Michael J. Pencina
Format: Article
Language:English
Published: Taylor & Francis Group 2017-07-01
Series:Statistical Theory and Related Fields
Subjects:
Online Access:http://dx.doi.org/10.1080/24754269.2017.1319105
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author Jialiang Li
Jason P. Fine
Michael J. Pencina
author_facet Jialiang Li
Jason P. Fine
Michael J. Pencina
author_sort Jialiang Li
collection DOAJ
description We provide a detailed review for the statistical analysis of diagnostic accuracy in a multi-category classification task. For qualitative response variables with more than two categories, many traditional accuracy measures such as sensitivity, specificity and area under the ROC curve are no longer applicable. In recent literature, new diagnostic accuracy measures are introduced in medical research studies. In this paper, important statistical concepts for multi-category classification accuracy are reviewed and their utilities are demonstrated with real medical examples. We offer problem-based R code to illustrate how to perform these statistical computations step by step. We expect such analysis tools will become more familiar to practitioners and receive broader applications in biostatistics. Our program can be adapted to many classifiers among which logistic regression may be the most popular approach. We thus base our discussion and illustration completely on the logistic regression in this paper.
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spelling doaj.art-c437c6ca6f6547529eb529136ba6802f2023-09-22T09:19:44ZengTaylor & Francis GroupStatistical Theory and Related Fields2475-42692475-42772017-07-011214315810.1080/24754269.2017.13191051319105Multi-category diagnostic accuracy based on logistic regressionJialiang Li0Jason P. Fine1Michael J. Pencina2Singapore Eye Research Institute, National University of SingaporeUniversity of North CarolinaDuke UniversityWe provide a detailed review for the statistical analysis of diagnostic accuracy in a multi-category classification task. For qualitative response variables with more than two categories, many traditional accuracy measures such as sensitivity, specificity and area under the ROC curve are no longer applicable. In recent literature, new diagnostic accuracy measures are introduced in medical research studies. In this paper, important statistical concepts for multi-category classification accuracy are reviewed and their utilities are demonstrated with real medical examples. We offer problem-based R code to illustrate how to perform these statistical computations step by step. We expect such analysis tools will become more familiar to practitioners and receive broader applications in biostatistics. Our program can be adapted to many classifiers among which logistic regression may be the most popular approach. We thus base our discussion and illustration completely on the logistic regression in this paper.http://dx.doi.org/10.1080/24754269.2017.1319105hypervolume under the roc manifoldmulti-category classificationcorrect classification probabilitynet reclassification improvementintegrated discrimination improvementmarker evaluationr software
spellingShingle Jialiang Li
Jason P. Fine
Michael J. Pencina
Multi-category diagnostic accuracy based on logistic regression
Statistical Theory and Related Fields
hypervolume under the roc manifold
multi-category classification
correct classification probability
net reclassification improvement
integrated discrimination improvement
marker evaluation
r software
title Multi-category diagnostic accuracy based on logistic regression
title_full Multi-category diagnostic accuracy based on logistic regression
title_fullStr Multi-category diagnostic accuracy based on logistic regression
title_full_unstemmed Multi-category diagnostic accuracy based on logistic regression
title_short Multi-category diagnostic accuracy based on logistic regression
title_sort multi category diagnostic accuracy based on logistic regression
topic hypervolume under the roc manifold
multi-category classification
correct classification probability
net reclassification improvement
integrated discrimination improvement
marker evaluation
r software
url http://dx.doi.org/10.1080/24754269.2017.1319105
work_keys_str_mv AT jialiangli multicategorydiagnosticaccuracybasedonlogisticregression
AT jasonpfine multicategorydiagnosticaccuracybasedonlogisticregression
AT michaeljpencina multicategorydiagnosticaccuracybasedonlogisticregression