Modulation of cAMP metabolism for CFTR potentiation in human airway epithelial cells

Modulation of cAMP metabolism for CFTR potentiation in human airway epithelial cells

Abstract Cystic fibrosis (CF) is a genetic disease characterized by CF transmembrane regulator (CFTR) dysfunction. With over 2000 CFTR variants identified, in addition to known patient to patient variability, there is a need for personalized treatment. The discovery of CFTR modulators has shown effi...

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Bibliographic Details
Main Authors:	Jenny P. Nguyen, Matthew Bianca, Ryan D. Huff, Nicholas Tiessen, Mark D. Inman, Jeremy A. Hirota
Format:	Article
Language:	English
Published:	Nature Portfolio 2021-01-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-020-79555-w

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