Poly(Ethylene Glycol)–Polylactide Micelles for Cancer Therapy
For the treatment of malignancy, many therapeutic agents, including small molecules, photosensitizers, immunomodulators, proteins and genes, and so forth, have been loaded into nanocarriers for controllable cancer therapy. Among these nanocarriers, polymeric micelles have been considered as one of t...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-03-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fphar.2018.00202/full |
| _version_ | 1811310870149464064 |
|---|---|
| author | Jixue Wang Jixue Wang Shengxian Li Shengxian Li Yuping Han Jingjing Guan Shirley Chung Chunxi Wang Di Li |
| author_facet | Jixue Wang Jixue Wang Shengxian Li Shengxian Li Yuping Han Jingjing Guan Shirley Chung Chunxi Wang Di Li |
| author_sort | Jixue Wang |
| collection | DOAJ |
| description | For the treatment of malignancy, many therapeutic agents, including small molecules, photosensitizers, immunomodulators, proteins and genes, and so forth, have been loaded into nanocarriers for controllable cancer therapy. Among these nanocarriers, polymeric micelles have been considered as one of the most promising nanocarriers, some of which have already been applied in different stages of clinical trials. The successful advantages of polymeric micelles from bench to bedside are due to their special core/shell structures, which can carry specific drugs in certain disease conditions. Particularly, poly(ethylene glycol)–polylactide (PEG–PLA) micelles have been considered as one of the most promising platforms for drug delivery. The PEG shell effectively prevents the adsorption of proteins and phagocytes, thereby evidently extending the blood circulation period. Meanwhile, the hydrophobic PLA core can effectively encapsulate many therapeutic agents. This review summarizes recent advances in PEG–PLA micelles for the treatment of malignancy. In addition, future perspectives for the development of PEG–PLA micelles as drug delivery systems are also presented. |
| first_indexed | 2024-04-13T10:06:39Z |
| format | Article |
| id | doaj.art-c43c4879565c408090041d3dcce9ab71 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T10:06:39Z |
| publishDate | 2018-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-c43c4879565c408090041d3dcce9ab712022-12-22T02:51:04ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-03-01910.3389/fphar.2018.00202350470Poly(Ethylene Glycol)–Polylactide Micelles for Cancer TherapyJixue Wang0Jixue Wang1Shengxian Li2Shengxian Li3Yuping Han4Jingjing Guan5Shirley Chung6Chunxi Wang7Di Li8Department of Urology, The First Hospital of Jilin University, Changchun, ChinaKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, ChinaDepartment of Urology, The First Hospital of Jilin University, Changchun, ChinaKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, ChinaDepartment of Urology, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Urology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Biology, University of Waterloo, Waterloo, ON, CanadaDepartment of Urology, The First Hospital of Jilin University, Changchun, ChinaKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, ChinaFor the treatment of malignancy, many therapeutic agents, including small molecules, photosensitizers, immunomodulators, proteins and genes, and so forth, have been loaded into nanocarriers for controllable cancer therapy. Among these nanocarriers, polymeric micelles have been considered as one of the most promising nanocarriers, some of which have already been applied in different stages of clinical trials. The successful advantages of polymeric micelles from bench to bedside are due to their special core/shell structures, which can carry specific drugs in certain disease conditions. Particularly, poly(ethylene glycol)–polylactide (PEG–PLA) micelles have been considered as one of the most promising platforms for drug delivery. The PEG shell effectively prevents the adsorption of proteins and phagocytes, thereby evidently extending the blood circulation period. Meanwhile, the hydrophobic PLA core can effectively encapsulate many therapeutic agents. This review summarizes recent advances in PEG–PLA micelles for the treatment of malignancy. In addition, future perspectives for the development of PEG–PLA micelles as drug delivery systems are also presented.http://journal.frontiersin.org/article/10.3389/fphar.2018.00202/fullpolylactidepoly(ethylene glycol)micellenanocarriercontrolled drug releaseantitumor treatment |
| spellingShingle | Jixue Wang Jixue Wang Shengxian Li Shengxian Li Yuping Han Jingjing Guan Shirley Chung Chunxi Wang Di Li Poly(Ethylene Glycol)–Polylactide Micelles for Cancer Therapy Frontiers in Pharmacology polylactide poly(ethylene glycol) micelle nanocarrier controlled drug release antitumor treatment |
| title | Poly(Ethylene Glycol)–Polylactide Micelles for Cancer Therapy |
| title_full | Poly(Ethylene Glycol)–Polylactide Micelles for Cancer Therapy |
| title_fullStr | Poly(Ethylene Glycol)–Polylactide Micelles for Cancer Therapy |
| title_full_unstemmed | Poly(Ethylene Glycol)–Polylactide Micelles for Cancer Therapy |
| title_short | Poly(Ethylene Glycol)–Polylactide Micelles for Cancer Therapy |
| title_sort | poly ethylene glycol polylactide micelles for cancer therapy |
| topic | polylactide poly(ethylene glycol) micelle nanocarrier controlled drug release antitumor treatment |
| url | http://journal.frontiersin.org/article/10.3389/fphar.2018.00202/full |
| work_keys_str_mv | AT jixuewang polyethyleneglycolpolylactidemicellesforcancertherapy AT jixuewang polyethyleneglycolpolylactidemicellesforcancertherapy AT shengxianli polyethyleneglycolpolylactidemicellesforcancertherapy AT shengxianli polyethyleneglycolpolylactidemicellesforcancertherapy AT yupinghan polyethyleneglycolpolylactidemicellesforcancertherapy AT jingjingguan polyethyleneglycolpolylactidemicellesforcancertherapy AT shirleychung polyethyleneglycolpolylactidemicellesforcancertherapy AT chunxiwang polyethyleneglycolpolylactidemicellesforcancertherapy AT dili polyethyleneglycolpolylactidemicellesforcancertherapy |