Tumor PKCδ instigates immune exclusion in EGFR-mutated non–small cell lung cancer

Tumor PKCδ instigates immune exclusion in EGFR-mutated non–small cell lung cancer

Abstract Background The recruitment of a sufficient number of immune cells to induce an inflamed tumor microenvironment (TME) is a prerequisite for effective response to cancer immunotherapy. The immunological phenotypes in the TME of EGFR–mutated lung cancer were characterized as non-inflamed, for...

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Bibliographic Details
Main Authors: Yi-Han Zuo, Wei-Na Gao, Ya-Jia Xie, Sheng-Yong Yang, Jin-Tai Zhou, Hai-Hai Liang, Xing-Xing Fan
Format: Article
Language:English
Published: BMC 2022-12-01
Series:BMC Medicine
Subjects:
Tumor microenvironment
Immune checkpoint
Tumor infiltrating lymphocytes
PKCδ
PD-1
Online Access:https://doi.org/10.1186/s12916-022-02670-0

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