The journey of antimalarial drugs against SARS-CoV-2: Review article
The recent outbreak of coronavirus pandemic (COVID-19) introduced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has greatly affected the global public health. This pandemic disease became particularly threatening after the start of a new wave. Vaccines of tested efficacy to stop CO...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | Informatics in Medicine Unlocked |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352914821000940 |
| _version_ | 1818865176233902080 |
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| author | Amany A. Sarhan Nada A. Ashour Ahmed A. Al‐Karmalawy |
| author_facet | Amany A. Sarhan Nada A. Ashour Ahmed A. Al‐Karmalawy |
| author_sort | Amany A. Sarhan |
| collection | DOAJ |
| description | The recent outbreak of coronavirus pandemic (COVID-19) introduced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has greatly affected the global public health. This pandemic disease became particularly threatening after the start of a new wave. Vaccines of tested efficacy to stop COVID-19 infection are being investigated vigorously worldwide. Currently, some specific drugs have been authorized for COVID-19, but the improvement of antivirals requires time. Hence, a faster way of treatment is done by drug repurposing. Repurposing of drugs is promising for treating and reducing the symptoms of the disease, and it a fast, easy, and safe method to address the crisis, because of their previously known applications. Some antimalarial drugs, especially chloroquine and hydroxychloroquine, have been repurposed, as they exhibited promising results in vitro and in vivo. This article investigates repurposed antimalarial drugs, focusing on their antiviral mechanisms of action, effects in combinations, trial results, and their side effects. |
| first_indexed | 2024-12-19T10:43:23Z |
| format | Article |
| id | doaj.art-c43d05879f7b4daabd271c705038894c |
| institution | Directory Open Access Journal |
| issn | 2352-9148 |
| language | English |
| last_indexed | 2024-12-19T10:43:23Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Informatics in Medicine Unlocked |
| spelling | doaj.art-c43d05879f7b4daabd271c705038894c2022-12-21T20:25:21ZengElsevierInformatics in Medicine Unlocked2352-91482021-01-0124100604The journey of antimalarial drugs against SARS-CoV-2: Review articleAmany A. Sarhan0Nada A. Ashour1Ahmed A. Al‐Karmalawy2Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta, 34518, EgyptDepartment of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta, 34518, EgyptCorresponding author.; Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta, 34518, EgyptThe recent outbreak of coronavirus pandemic (COVID-19) introduced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has greatly affected the global public health. This pandemic disease became particularly threatening after the start of a new wave. Vaccines of tested efficacy to stop COVID-19 infection are being investigated vigorously worldwide. Currently, some specific drugs have been authorized for COVID-19, but the improvement of antivirals requires time. Hence, a faster way of treatment is done by drug repurposing. Repurposing of drugs is promising for treating and reducing the symptoms of the disease, and it a fast, easy, and safe method to address the crisis, because of their previously known applications. Some antimalarial drugs, especially chloroquine and hydroxychloroquine, have been repurposed, as they exhibited promising results in vitro and in vivo. This article investigates repurposed antimalarial drugs, focusing on their antiviral mechanisms of action, effects in combinations, trial results, and their side effects.http://www.sciencedirect.com/science/article/pii/S2352914821000940COIVD-19Anti-malarial drugsDrug repurposingCombination therapy |
| spellingShingle | Amany A. Sarhan Nada A. Ashour Ahmed A. Al‐Karmalawy The journey of antimalarial drugs against SARS-CoV-2: Review article Informatics in Medicine Unlocked COIVD-19 Anti-malarial drugs Drug repurposing Combination therapy |
| title | The journey of antimalarial drugs against SARS-CoV-2: Review article |
| title_full | The journey of antimalarial drugs against SARS-CoV-2: Review article |
| title_fullStr | The journey of antimalarial drugs against SARS-CoV-2: Review article |
| title_full_unstemmed | The journey of antimalarial drugs against SARS-CoV-2: Review article |
| title_short | The journey of antimalarial drugs against SARS-CoV-2: Review article |
| title_sort | journey of antimalarial drugs against sars cov 2 review article |
| topic | COIVD-19 Anti-malarial drugs Drug repurposing Combination therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2352914821000940 |
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