Amantadine Improves Delayed Neuropsychiatric Sequelae of Carbon Monoxide Poisoning: A Case Report
Carbon monoxide (CO) poisoning causes severe brain damage, including delayed neuropsychiatric sequelae (DNS), which occur after a lucid interval following recovery from the insult of acute CO poisoning. We describe a 39-year-old male who developed DNS, including gait disturbance, trunk ataxia, and f...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-10-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/9/11/292 |
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| author | Tomosuke Nakano Toshiki Hasegawa Dai Suzuki Eishi Motomura Motohiro Okada |
| author_facet | Tomosuke Nakano Toshiki Hasegawa Dai Suzuki Eishi Motomura Motohiro Okada |
| author_sort | Tomosuke Nakano |
| collection | DOAJ |
| description | Carbon monoxide (CO) poisoning causes severe brain damage, including delayed neuropsychiatric sequelae (DNS), which occur after a lucid interval following recovery from the insult of acute CO poisoning. We describe a 39-year-old male who developed DNS, including gait disturbance, trunk ataxia, and fecal/urine incontinence, after remission of acute CO poisoning. Furthermore, he showed confusion, with disorientation in terms of time and space. All symptoms, including cognitive impairment, were dramatically improved by amantadine monotherapy. The present case illustrates the possibility of amantadine treatment for cognitive impairment as well as Parkinsonism induced by CO poisoning. |
| first_indexed | 2024-12-14T10:27:18Z |
| format | Article |
| id | doaj.art-c43d8a38acd2487bb66e7b8b7e7089a0 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-12-14T10:27:18Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-c43d8a38acd2487bb66e7b8b7e7089a02022-12-21T23:06:17ZengMDPI AGBrain Sciences2076-34252019-10-0191129210.3390/brainsci9110292brainsci9110292Amantadine Improves Delayed Neuropsychiatric Sequelae of Carbon Monoxide Poisoning: A Case ReportTomosuke Nakano0Toshiki Hasegawa1Dai Suzuki2Eishi Motomura3Motohiro Okada4Department of Neuropsychiatry, Mie University Graduate School of Medicine, 2-174, Edobashi, Tsu, Mie 514-8507, JapanDepartment of Neuropsychiatry, Mie University Graduate School of Medicine, 2-174, Edobashi, Tsu, Mie 514-8507, JapanDepartment of Neuropsychiatry, Mie University Graduate School of Medicine, 2-174, Edobashi, Tsu, Mie 514-8507, JapanDepartment of Neuropsychiatry, Mie University Graduate School of Medicine, 2-174, Edobashi, Tsu, Mie 514-8507, JapanDepartment of Neuropsychiatry, Mie University Graduate School of Medicine, 2-174, Edobashi, Tsu, Mie 514-8507, JapanCarbon monoxide (CO) poisoning causes severe brain damage, including delayed neuropsychiatric sequelae (DNS), which occur after a lucid interval following recovery from the insult of acute CO poisoning. We describe a 39-year-old male who developed DNS, including gait disturbance, trunk ataxia, and fecal/urine incontinence, after remission of acute CO poisoning. Furthermore, he showed confusion, with disorientation in terms of time and space. All symptoms, including cognitive impairment, were dramatically improved by amantadine monotherapy. The present case illustrates the possibility of amantadine treatment for cognitive impairment as well as Parkinsonism induced by CO poisoning.https://www.mdpi.com/2076-3425/9/11/292amantadinecarbon monoxide poisoningdelayed neuropsychiatric sequelaenmda-r antagonist |
| spellingShingle | Tomosuke Nakano Toshiki Hasegawa Dai Suzuki Eishi Motomura Motohiro Okada Amantadine Improves Delayed Neuropsychiatric Sequelae of Carbon Monoxide Poisoning: A Case Report Brain Sciences amantadine carbon monoxide poisoning delayed neuropsychiatric sequelae nmda-r antagonist |
| title | Amantadine Improves Delayed Neuropsychiatric Sequelae of Carbon Monoxide Poisoning: A Case Report |
| title_full | Amantadine Improves Delayed Neuropsychiatric Sequelae of Carbon Monoxide Poisoning: A Case Report |
| title_fullStr | Amantadine Improves Delayed Neuropsychiatric Sequelae of Carbon Monoxide Poisoning: A Case Report |
| title_full_unstemmed | Amantadine Improves Delayed Neuropsychiatric Sequelae of Carbon Monoxide Poisoning: A Case Report |
| title_short | Amantadine Improves Delayed Neuropsychiatric Sequelae of Carbon Monoxide Poisoning: A Case Report |
| title_sort | amantadine improves delayed neuropsychiatric sequelae of carbon monoxide poisoning a case report |
| topic | amantadine carbon monoxide poisoning delayed neuropsychiatric sequelae nmda-r antagonist |
| url | https://www.mdpi.com/2076-3425/9/11/292 |
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