Macrophages in Renal Injury, Repair, Fibrosis Following Acute Kidney Injury and Targeted Therapy
Acute kidney injury (AKI) is a renal disease with a high incidence and mortality. Currently, there are no targeted therapeutics for preventing and treating AKI. Macrophages, important players in mammalian immune response, are involved in the multiple pathological processes of AKI. They are dynamical...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.934299/full |
| _version_ | 1811292255362744320 |
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| author | Hui Chen Na Liu Shougang Zhuang Shougang Zhuang |
| author_facet | Hui Chen Na Liu Shougang Zhuang Shougang Zhuang |
| author_sort | Hui Chen |
| collection | DOAJ |
| description | Acute kidney injury (AKI) is a renal disease with a high incidence and mortality. Currently, there are no targeted therapeutics for preventing and treating AKI. Macrophages, important players in mammalian immune response, are involved in the multiple pathological processes of AKI. They are dynamically activated and exhibit a diverse spectrum of functional phenotypes in the kidney after AKI. Targeting the mechanisms of macrophage activation significantly improves the outcomes of AKI in preclinical studies. In this review, we summarize the role of macrophages and the underlying mechanisms of macrophage activation during kidney injury, repair, regeneration, and fibrosis and provide strategies for macrophage-targeted therapies. |
| first_indexed | 2024-04-13T04:42:41Z |
| format | Article |
| id | doaj.art-c43e531f3e12439f9eb1558b8c9bb27a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T04:42:41Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-c43e531f3e12439f9eb1558b8c9bb27a2022-12-22T03:01:56ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-07-011310.3389/fimmu.2022.934299934299Macrophages in Renal Injury, Repair, Fibrosis Following Acute Kidney Injury and Targeted TherapyHui Chen0Na Liu1Shougang Zhuang2Shougang Zhuang3Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Medicine, Rhode Island Hospital and Alpert Medical School, Brown University, Providence, RI, United StatesAcute kidney injury (AKI) is a renal disease with a high incidence and mortality. Currently, there are no targeted therapeutics for preventing and treating AKI. Macrophages, important players in mammalian immune response, are involved in the multiple pathological processes of AKI. They are dynamically activated and exhibit a diverse spectrum of functional phenotypes in the kidney after AKI. Targeting the mechanisms of macrophage activation significantly improves the outcomes of AKI in preclinical studies. In this review, we summarize the role of macrophages and the underlying mechanisms of macrophage activation during kidney injury, repair, regeneration, and fibrosis and provide strategies for macrophage-targeted therapies.https://www.frontiersin.org/articles/10.3389/fimmu.2022.934299/fullmacrophageskidneyinflammationrepairregenerationfibrosis |
| spellingShingle | Hui Chen Na Liu Shougang Zhuang Shougang Zhuang Macrophages in Renal Injury, Repair, Fibrosis Following Acute Kidney Injury and Targeted Therapy Frontiers in Immunology macrophages kidney inflammation repair regeneration fibrosis |
| title | Macrophages in Renal Injury, Repair, Fibrosis Following Acute Kidney Injury and Targeted Therapy |
| title_full | Macrophages in Renal Injury, Repair, Fibrosis Following Acute Kidney Injury and Targeted Therapy |
| title_fullStr | Macrophages in Renal Injury, Repair, Fibrosis Following Acute Kidney Injury and Targeted Therapy |
| title_full_unstemmed | Macrophages in Renal Injury, Repair, Fibrosis Following Acute Kidney Injury and Targeted Therapy |
| title_short | Macrophages in Renal Injury, Repair, Fibrosis Following Acute Kidney Injury and Targeted Therapy |
| title_sort | macrophages in renal injury repair fibrosis following acute kidney injury and targeted therapy |
| topic | macrophages kidney inflammation repair regeneration fibrosis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.934299/full |
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