The role of mitochondria in pharmacological ascorbate-induced toxicity

The role of mitochondria in pharmacological ascorbate-induced toxicity

Abstract At pharmacological levels, ascorbate (P-AscH-) acts as a pro-oxidant by generating H2O2, depleting ATP in sensitive cells leading to cell death. The aim of this study was to determine the role of ATP production by oxidative phosphorylation or glycolysis in mechanisms of resistance to P-AscH...

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Bibliographic Details
Main Authors: Juan Du, Amanda N. Pope, Brianne R. O’Leary, Brett A. Wagner, Prabhat C. Goswami, Garry R. Buettner, Joseph J. Cullen
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-27185-9

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