Memory T-cell enriched haploidentical transplantation with NK cell addback results in promising long-term outcomes: a phase II trial

Memory T-cell enriched haploidentical transplantation with NK cell addback results in promising long-term outcomes: a phase II trial

Abstract Background Relapse remains a challenge after transplantation in pediatric patients with hematological malignancies. Myeloablative regimens used for disease control are associated with acute and long-term adverse effects. We used a CD45RA-depleted haploidentical graft for adoptive transfer o...

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Bibliographic Details
Main Authors: Swati Naik, Ying Li, Aimee C. Talleur, Subodh Selukar, Emily Ashcraft, Cheng Cheng, Renee M. Madden, Ewelina Mamcarz, Amr Qudeimat, Akshay Sharma, Ashok Srinivasan, Ali Y. Suliman, Rebecca Epperly, Esther A. Obeng, M. Paulina Velasquez, Deanna Langfitt, Sarah Schell, Jean-Yves Métais, Paula Y. Arnold, Diego R. Hijano, Gabriela Maron, Thomas E. Merchant, Salem Akel, Wing Leung, Stephen Gottschalk, Brandon M. Triplett
Format: Article
Language:English
Published: BMC 2024-06-01
Series:Journal of Hematology & Oncology
Subjects:
Pediatric hematological malignancies
Transplantation
Haploidentical
Memory T cell
T-cell depletion
CD45RA depletion
Online Access:https://doi.org/10.1186/s13045-024-01567-0

Internet

https://doi.org/10.1186/s13045-024-01567-0

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