State of the art procedures towards reactive [18F]fluoride in PET tracer synthesis
Abstract Background Positron emission tomography (PET) is a powerful, non-invasive preclinical and clinical nuclear imaging technique used in disease diagnosis and therapy assessment. Fluorine-18 is the predominant radionuclide used for PET tracer synthesis. An impressive variety of new ‘late-stage’...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-10-01
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| Series: | EJNMMI Radiopharmacy and Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41181-023-00203-5 |
| _version_ | 1797451006708023296 |
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| author | Lizeth Y. F. Haveman Danielle J. Vugts Albert D. Windhorst |
| author_facet | Lizeth Y. F. Haveman Danielle J. Vugts Albert D. Windhorst |
| author_sort | Lizeth Y. F. Haveman |
| collection | DOAJ |
| description | Abstract Background Positron emission tomography (PET) is a powerful, non-invasive preclinical and clinical nuclear imaging technique used in disease diagnosis and therapy assessment. Fluorine-18 is the predominant radionuclide used for PET tracer synthesis. An impressive variety of new ‘late-stage’ radiolabeling methodologies for the preparation of 18F-labeled tracers has appeared in order to improve the efficiency of the labeling reaction. Main body Despite these developments, one outstanding challenge into the early key steps of the process remains: the preparation of reactive [18F]fluoride from oxygen-18 enriched water ([18O]H2O). In the last decade, significant changes into the trapping, elution and drying stages have been introduced. This review provides an overview of the strategies and recent developments in the production of reactive [18F]fluoride and its use for radiolabeling. Conclusion Improved, modified or even completely new fluorine-18 work-up procedures have been developed in the last decade with widespread use in base-sensitive nucleophilic 18F-fluorination reactions. The many promising developments may lead to a few standardized drying methodologies for the routine production of a broad scale of PET tracers. |
| first_indexed | 2024-03-09T14:48:42Z |
| format | Article |
| id | doaj.art-c441d1b7df3c4c29ab3acf5ac9bf233c |
| institution | Directory Open Access Journal |
| issn | 2365-421X |
| language | English |
| last_indexed | 2024-03-09T14:48:42Z |
| publishDate | 2023-10-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Radiopharmacy and Chemistry |
| spelling | doaj.art-c441d1b7df3c4c29ab3acf5ac9bf233c2023-11-26T14:37:27ZengSpringerOpenEJNMMI Radiopharmacy and Chemistry2365-421X2023-10-018113110.1186/s41181-023-00203-5State of the art procedures towards reactive [18F]fluoride in PET tracer synthesisLizeth Y. F. Haveman0Danielle J. Vugts1Albert D. Windhorst2Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit AmsterdamRadiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit AmsterdamRadiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit AmsterdamAbstract Background Positron emission tomography (PET) is a powerful, non-invasive preclinical and clinical nuclear imaging technique used in disease diagnosis and therapy assessment. Fluorine-18 is the predominant radionuclide used for PET tracer synthesis. An impressive variety of new ‘late-stage’ radiolabeling methodologies for the preparation of 18F-labeled tracers has appeared in order to improve the efficiency of the labeling reaction. Main body Despite these developments, one outstanding challenge into the early key steps of the process remains: the preparation of reactive [18F]fluoride from oxygen-18 enriched water ([18O]H2O). In the last decade, significant changes into the trapping, elution and drying stages have been introduced. This review provides an overview of the strategies and recent developments in the production of reactive [18F]fluoride and its use for radiolabeling. Conclusion Improved, modified or even completely new fluorine-18 work-up procedures have been developed in the last decade with widespread use in base-sensitive nucleophilic 18F-fluorination reactions. The many promising developments may lead to a few standardized drying methodologies for the routine production of a broad scale of PET tracers.https://doi.org/10.1186/s41181-023-00203-5Radiopharmaceutical chemistryFluorine-18 |
| spellingShingle | Lizeth Y. F. Haveman Danielle J. Vugts Albert D. Windhorst State of the art procedures towards reactive [18F]fluoride in PET tracer synthesis EJNMMI Radiopharmacy and Chemistry Radiopharmaceutical chemistry Fluorine-18 |
| title | State of the art procedures towards reactive [18F]fluoride in PET tracer synthesis |
| title_full | State of the art procedures towards reactive [18F]fluoride in PET tracer synthesis |
| title_fullStr | State of the art procedures towards reactive [18F]fluoride in PET tracer synthesis |
| title_full_unstemmed | State of the art procedures towards reactive [18F]fluoride in PET tracer synthesis |
| title_short | State of the art procedures towards reactive [18F]fluoride in PET tracer synthesis |
| title_sort | state of the art procedures towards reactive 18f fluoride in pet tracer synthesis |
| topic | Radiopharmaceutical chemistry Fluorine-18 |
| url | https://doi.org/10.1186/s41181-023-00203-5 |
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