Blocking P2X7 receptor with AZ 10606120 exacerbates vascular hyperpermeability and inflammation in murine polymicrobial sepsis

Blocking P2X7 receptor with AZ 10606120 exacerbates vascular hyperpermeability and inflammation in murine polymicrobial sepsis

Abstract Sepsis is a devastating disease with high morbidity and mortality and no specific treatments. The pathophysiology of sepsis involves a hyperinflammatory response and release of damage‐associated molecular patterns (DAMPs), including adenosine triphosphate (ATP), from activated and dying cel...

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Bibliographic Details
Main Authors: Jamie E. Meegan, Padmini Komalavilas, Joyce Cheung‐Flynn, Tsz Wing Yim, Nathan D. Putz, Jordan J. Jesse, Kyle D. Smith, Tatiana N. Sidorova, Han Noo Ri Lee, Toria Tomasek, Ciara M. Shaver, Lorraine B. Ware, Colleen M. Brophy, Julie A. Bastarache
Format: Article
Language:English
Published: Wiley 2022-06-01
Series:Physiological Reports
Subjects:
AZ 10606120
inflammation
P2X7R
sepsis
vascular dysfunction
Online Access:https://doi.org/10.14814/phy2.15290

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