Treatment Results in Serpiginous Choroiditis and Multifocal Serpiginoid Choroiditis Associated with Latent Tuberculosis
Objectives: To compare the results of systemic antitubercular therapy (ATT) and immunomodulatory therapy (IMT) in patients with serpiginous choroiditis (SC) or multifocal serpiginoid choroiditis (MSC). Materials and Methods: The clinical records of 28 patients with SC and MSC were reviewed. Patient...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2017-03-01
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| Series: | Türk Oftalmoloji Dergisi |
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| Online Access: | http://www.oftalmoloji.org/article_14762/Treatment-Results-In-Serpiginous-Choroiditis-And-Multifocal-Serpiginoid-Choroiditis-Associated-With-Latent-Tuberculosis |
| _version_ | 1797916109019545600 |
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| author | Merih Oray Zaur Zakiev Tülin Çağatay İlknur Tuğal-Tutkun |
| author_facet | Merih Oray Zaur Zakiev Tülin Çağatay İlknur Tuğal-Tutkun |
| author_sort | Merih Oray |
| collection | DOAJ |
| description | Objectives: To compare the results of systemic antitubercular therapy (ATT) and immunomodulatory therapy (IMT) in patients with serpiginous choroiditis (SC) or multifocal serpiginoid choroiditis (MSC).
Materials and Methods: The clinical records of 28 patients with SC and MSC were reviewed. Patients were divided into 2 groups according to the treatment applied. Group 1 included 12 patients with MSC and 5 with SC treated with ATT and corticosteroid (CS); group 2 included 9 patients with MSC and 2 with SC treated with conventional IMT, interferon alpha-2a, and/or CS monotherapy.
Results: In group 1, clinical remission was achieved in 12/12 MSC and 3/5 SC (total 15/17) patients with administration of ATT for 1 year. Two patients (1 SC, 1 MSC) had reactivation 2 and 7 months after cessation of ATT. Two patients with recurrence after completion of ATT and 2 patients resistant to ATT received IMT ± CS therapy. In group 2, clinical remission was achieved in 7/9 MSC and 2/2 SC (total 9/11) patients after 1 year of treatment. Recurrent inflammation was observed in 2 MSC patients 2 and 112 months after initiation of therapy, but responded well to local/systemic CS or IMT modification, and clinical remission was achieved in 7.8±4.3 months. Cumulative dose of CS was higher in group 2 (p=0.057). Nine of 12 MSC patients treated with ATT and 4/9 MSC patients treated with IMT achieved remission (p=0.203). One of 5 SC patients treated with ATT and 2/2 SC patients treated with IMT achieved remission (p=0.142).
Conclusion: Although a statistically significant result could not be achieved in this small case series, our results suggest that ATT may be an appropriate first choice in the treatment of MSC associated with latent tuberculosis, and may be administered in patients with SC who are unresponsive to IMT. |
| first_indexed | 2024-04-10T12:53:10Z |
| format | Article |
| id | doaj.art-c442c7499d8e46c18c2c233bec64a990 |
| institution | Directory Open Access Journal |
| issn | 1300-0659 2147-2661 |
| language | English |
| last_indexed | 2024-04-10T12:53:10Z |
| publishDate | 2017-03-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Oftalmoloji Dergisi |
| spelling | doaj.art-c442c7499d8e46c18c2c233bec64a9902023-02-15T16:13:41ZengGalenos YayineviTürk Oftalmoloji Dergisi1300-06592147-26612017-03-01472899310.4274/tjo.37630Treatment Results in Serpiginous Choroiditis and Multifocal Serpiginoid Choroiditis Associated with Latent TuberculosisMerih Oray0Zaur Zakiev1Tülin Çağatay2İlknur Tuğal-Tutkun3İstanbul University İstanbul Faculty of Medicine, Department of Ophthalmology, İstanbul, Turkeyİstanbul University İstanbul Faculty of Medicine, Department of Ophthalmology, İstanbul, Turkeyİstanbul University İstanbul Faculty of Medicine, Department of Pulmonary Medicine, İstanbul, Turkeyİstanbul University İstanbul Faculty of Medicine, Department of Ophthalmology, İstanbul, TurkeyObjectives: To compare the results of systemic antitubercular therapy (ATT) and immunomodulatory therapy (IMT) in patients with serpiginous choroiditis (SC) or multifocal serpiginoid choroiditis (MSC). Materials and Methods: The clinical records of 28 patients with SC and MSC were reviewed. Patients were divided into 2 groups according to the treatment applied. Group 1 included 12 patients with MSC and 5 with SC treated with ATT and corticosteroid (CS); group 2 included 9 patients with MSC and 2 with SC treated with conventional IMT, interferon alpha-2a, and/or CS monotherapy. Results: In group 1, clinical remission was achieved in 12/12 MSC and 3/5 SC (total 15/17) patients with administration of ATT for 1 year. Two patients (1 SC, 1 MSC) had reactivation 2 and 7 months after cessation of ATT. Two patients with recurrence after completion of ATT and 2 patients resistant to ATT received IMT ± CS therapy. In group 2, clinical remission was achieved in 7/9 MSC and 2/2 SC (total 9/11) patients after 1 year of treatment. Recurrent inflammation was observed in 2 MSC patients 2 and 112 months after initiation of therapy, but responded well to local/systemic CS or IMT modification, and clinical remission was achieved in 7.8±4.3 months. Cumulative dose of CS was higher in group 2 (p=0.057). Nine of 12 MSC patients treated with ATT and 4/9 MSC patients treated with IMT achieved remission (p=0.203). One of 5 SC patients treated with ATT and 2/2 SC patients treated with IMT achieved remission (p=0.142). Conclusion: Although a statistically significant result could not be achieved in this small case series, our results suggest that ATT may be an appropriate first choice in the treatment of MSC associated with latent tuberculosis, and may be administered in patients with SC who are unresponsive to IMT.http://www.oftalmoloji.org/article_14762/Treatment-Results-In-Serpiginous-Choroiditis-And-Multifocal-Serpiginoid-Choroiditis-Associated-With-Latent-TuberculosisSerpiginous choroiditismultifocal serpiginoid choroiditislatent tuberculosisanti tubercular therapyimmunomodulatory treatment |
| spellingShingle | Merih Oray Zaur Zakiev Tülin Çağatay İlknur Tuğal-Tutkun Treatment Results in Serpiginous Choroiditis and Multifocal Serpiginoid Choroiditis Associated with Latent Tuberculosis Türk Oftalmoloji Dergisi Serpiginous choroiditis multifocal serpiginoid choroiditis latent tuberculosis anti tubercular therapy immunomodulatory treatment |
| title | Treatment Results in Serpiginous Choroiditis and Multifocal Serpiginoid Choroiditis Associated with Latent Tuberculosis |
| title_full | Treatment Results in Serpiginous Choroiditis and Multifocal Serpiginoid Choroiditis Associated with Latent Tuberculosis |
| title_fullStr | Treatment Results in Serpiginous Choroiditis and Multifocal Serpiginoid Choroiditis Associated with Latent Tuberculosis |
| title_full_unstemmed | Treatment Results in Serpiginous Choroiditis and Multifocal Serpiginoid Choroiditis Associated with Latent Tuberculosis |
| title_short | Treatment Results in Serpiginous Choroiditis and Multifocal Serpiginoid Choroiditis Associated with Latent Tuberculosis |
| title_sort | treatment results in serpiginous choroiditis and multifocal serpiginoid choroiditis associated with latent tuberculosis |
| topic | Serpiginous choroiditis multifocal serpiginoid choroiditis latent tuberculosis anti tubercular therapy immunomodulatory treatment |
| url | http://www.oftalmoloji.org/article_14762/Treatment-Results-In-Serpiginous-Choroiditis-And-Multifocal-Serpiginoid-Choroiditis-Associated-With-Latent-Tuberculosis |
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