Pharmacokinetics and pharmacodynamics of propranolol in hypertensive patients after sublingual administration: systemic availability

Pharmacokinetics and pharmacodynamics of propranolol in hypertensive patients after sublingual administration: systemic availability

The bioavailability of propranolol depends on the degree of liver metabolism. Orally but not intravenously administered propranolol is heavily metabolized. In the present study we assessed the pharmacokinetics and pharmacodynamics of sublingual propranolol. Fourteen severely hypertensive patients (d...

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Bibliographic Details
Main Authors:	A.P. Mansur, S.D. Avakian, R.S. Paula, H. Donzella, S.R.C.J. Santos, J.A.F. Ramires
Format:	Article
Language:	English
Published:	Associação Brasileira de Divulgação Científica 1998-05-01
Series:	Brazilian Journal of Medical and Biological Research
Subjects:	propranolol pharmacokinetics pharmacodynamics arterial hypertension sublingual vs peroral administration
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000500014

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