A CD300c-Fc Fusion Protein Inhibits T Cell Immunity
T cell responses are fine-tuned by co-stimulatory and co-inhibitory molecules. Among the T cell regulators, the B7 family members are of central importance. The recent success in targeting the B7 family molecules for the treatment of immune-related diseases has attracted intense interest in identify...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.02657/full |
| _version_ | 1819274877182410752 |
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| author | Cheng Cui Cheng Cui Min Su Yujun Lin Laijun Lai Laijun Lai |
| author_facet | Cheng Cui Cheng Cui Min Su Yujun Lin Laijun Lai Laijun Lai |
| author_sort | Cheng Cui |
| collection | DOAJ |
| description | T cell responses are fine-tuned by co-stimulatory and co-inhibitory molecules. Among the T cell regulators, the B7 family members are of central importance. The recent success in targeting the B7 family molecules for the treatment of immune-related diseases has attracted intense interest in identifying additional B7-related molecules. In this study, we describe CD300c as a novel T cell co-inhibitory molecule that shares significant sequence homology with existing B7 family members. CD300c protein is expressed on professional antigen-presenting cells (APC), including B cells, monocytes, macrophages, and dendritic cells (DCs). The putative CD300c counter-receptor is expressed on CD4 and CD8 T cells, and the expression levels are upregulated upon activation. Soluble human and mouse CD300c-Fc fusion proteins significantly inhibit the proliferation, activation, and cytokine production by CD4 and CD8 T cells in vitro. Administration of CD300c-Fc protein attenuates graft-vs.-host disease (GVHD) in mice. Our results suggest that therapeutic interaction with the CD300c inhibitory pathway may represent a new strategy to modulate T cell-mediated immunity for the treatment of GVHD and autoimmune disease. |
| first_indexed | 2024-12-23T23:15:24Z |
| format | Article |
| id | doaj.art-c4446c9b6fba44a09cdf73e122713dca |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-23T23:15:24Z |
| publishDate | 2018-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-c4446c9b6fba44a09cdf73e122713dca2022-12-21T17:26:31ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-11-01910.3389/fimmu.2018.02657418997A CD300c-Fc Fusion Protein Inhibits T Cell ImmunityCheng Cui0Cheng Cui1Min Su2Yujun Lin3Laijun Lai4Laijun Lai5Department of Allied Health Sciences, University of Connecticut, Storrs, CT, United StatesDepartment of Physiology, College of Basic Medical Science, China Medical University, Shenyang, ChinaDepartment of Allied Health Sciences, University of Connecticut, Storrs, CT, United StatesDepartment of Allied Health Sciences, University of Connecticut, Storrs, CT, United StatesDepartment of Allied Health Sciences, University of Connecticut, Storrs, CT, United StatesUniversity of Connecticut Stem Cell Institute, University of Connecticut, Storrs, CT, United StatesT cell responses are fine-tuned by co-stimulatory and co-inhibitory molecules. Among the T cell regulators, the B7 family members are of central importance. The recent success in targeting the B7 family molecules for the treatment of immune-related diseases has attracted intense interest in identifying additional B7-related molecules. In this study, we describe CD300c as a novel T cell co-inhibitory molecule that shares significant sequence homology with existing B7 family members. CD300c protein is expressed on professional antigen-presenting cells (APC), including B cells, monocytes, macrophages, and dendritic cells (DCs). The putative CD300c counter-receptor is expressed on CD4 and CD8 T cells, and the expression levels are upregulated upon activation. Soluble human and mouse CD300c-Fc fusion proteins significantly inhibit the proliferation, activation, and cytokine production by CD4 and CD8 T cells in vitro. Administration of CD300c-Fc protein attenuates graft-vs.-host disease (GVHD) in mice. Our results suggest that therapeutic interaction with the CD300c inhibitory pathway may represent a new strategy to modulate T cell-mediated immunity for the treatment of GVHD and autoimmune disease.https://www.frontiersin.org/article/10.3389/fimmu.2018.02657/fullT cell co-inhibitory moleculeB7 familyT cell proliferationT cell activationGVHD |
| spellingShingle | Cheng Cui Cheng Cui Min Su Yujun Lin Laijun Lai Laijun Lai A CD300c-Fc Fusion Protein Inhibits T Cell Immunity Frontiers in Immunology T cell co-inhibitory molecule B7 family T cell proliferation T cell activation GVHD |
| title | A CD300c-Fc Fusion Protein Inhibits T Cell Immunity |
| title_full | A CD300c-Fc Fusion Protein Inhibits T Cell Immunity |
| title_fullStr | A CD300c-Fc Fusion Protein Inhibits T Cell Immunity |
| title_full_unstemmed | A CD300c-Fc Fusion Protein Inhibits T Cell Immunity |
| title_short | A CD300c-Fc Fusion Protein Inhibits T Cell Immunity |
| title_sort | cd300c fc fusion protein inhibits t cell immunity |
| topic | T cell co-inhibitory molecule B7 family T cell proliferation T cell activation GVHD |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.02657/full |
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