Case report: Fundic gland polyps caused by long-term omeprazole use in a Maltese dog
Long-term use of proton-pump inhibitors can induce fundic gland polyps in the human stomach. However, this phenomenon has not been described in the veterinary literature. A 5-year-old intact female Maltese dog was referred to our hospital with chronic intermittent vomiting. The dog had been administ...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2023.1287335/full |
| _version_ | 1827787024871981056 |
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| author | Haemin Lee Sanggu Kim Dohee Lee Yeon Chae Taesik Yun Mhan-Pyo Yang Byeong-Teck Kang Soochong Kim Hakhyun Kim |
| author_facet | Haemin Lee Sanggu Kim Dohee Lee Yeon Chae Taesik Yun Mhan-Pyo Yang Byeong-Teck Kang Soochong Kim Hakhyun Kim |
| author_sort | Haemin Lee |
| collection | DOAJ |
| description | Long-term use of proton-pump inhibitors can induce fundic gland polyps in the human stomach. However, this phenomenon has not been described in the veterinary literature. A 5-year-old intact female Maltese dog was referred to our hospital with chronic intermittent vomiting. The dog had been administered omeprazole (0.7–1.0 mg/kg PO q24 h) for the management of hydrocephalus for over 4 years; the omeprazole dose was increased to 10 mg/kg PO q24 h 8 months prior to presentation at referring hospital. Abdominal ultrasonography revealed marked thickening of the gastric wall with multi-lobulated, thickened folds. Subsequent endoscopy revealed marked polypoid lesions, and histological examination of the biopsy samples was consistent with the fundic gland polyps associated with proton-pump inhibitor use in humans. The lesions resolved after cessation of omeprazole, as assessed by ultrasonography. This report describes a case of fundic gland polyps following the long-term administration of omeprazole in a dog. |
| first_indexed | 2024-03-11T16:43:40Z |
| format | Article |
| id | doaj.art-c4464a69d25b4635b00124dbfa2e9c8f |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-03-11T16:43:40Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-c4464a69d25b4635b00124dbfa2e9c8f2023-10-23T07:15:15ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692023-10-011010.3389/fvets.2023.12873351287335Case report: Fundic gland polyps caused by long-term omeprazole use in a Maltese dogHaemin Lee0Sanggu Kim1Dohee Lee2Yeon Chae3Taesik Yun4Mhan-Pyo Yang5Byeong-Teck Kang6Soochong Kim7Hakhyun Kim8Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of KoreaLaboratory of Veterinary Pathology and Platelet Signaling, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of KoreaLaboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of KoreaLaboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of KoreaLaboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of KoreaLaboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of KoreaLaboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of KoreaLaboratory of Veterinary Pathology and Platelet Signaling, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of KoreaLaboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of KoreaLong-term use of proton-pump inhibitors can induce fundic gland polyps in the human stomach. However, this phenomenon has not been described in the veterinary literature. A 5-year-old intact female Maltese dog was referred to our hospital with chronic intermittent vomiting. The dog had been administered omeprazole (0.7–1.0 mg/kg PO q24 h) for the management of hydrocephalus for over 4 years; the omeprazole dose was increased to 10 mg/kg PO q24 h 8 months prior to presentation at referring hospital. Abdominal ultrasonography revealed marked thickening of the gastric wall with multi-lobulated, thickened folds. Subsequent endoscopy revealed marked polypoid lesions, and histological examination of the biopsy samples was consistent with the fundic gland polyps associated with proton-pump inhibitor use in humans. The lesions resolved after cessation of omeprazole, as assessed by ultrasonography. This report describes a case of fundic gland polyps following the long-term administration of omeprazole in a dog.https://www.frontiersin.org/articles/10.3389/fvets.2023.1287335/fullcaninegastringastropathyproton-pump inhibitorvomiting |
| spellingShingle | Haemin Lee Sanggu Kim Dohee Lee Yeon Chae Taesik Yun Mhan-Pyo Yang Byeong-Teck Kang Soochong Kim Hakhyun Kim Case report: Fundic gland polyps caused by long-term omeprazole use in a Maltese dog Frontiers in Veterinary Science canine gastrin gastropathy proton-pump inhibitor vomiting |
| title | Case report: Fundic gland polyps caused by long-term omeprazole use in a Maltese dog |
| title_full | Case report: Fundic gland polyps caused by long-term omeprazole use in a Maltese dog |
| title_fullStr | Case report: Fundic gland polyps caused by long-term omeprazole use in a Maltese dog |
| title_full_unstemmed | Case report: Fundic gland polyps caused by long-term omeprazole use in a Maltese dog |
| title_short | Case report: Fundic gland polyps caused by long-term omeprazole use in a Maltese dog |
| title_sort | case report fundic gland polyps caused by long term omeprazole use in a maltese dog |
| topic | canine gastrin gastropathy proton-pump inhibitor vomiting |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2023.1287335/full |
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