Calcium polystyrene sulfonate associated colonic mucosal injury—innocent bystander or pathogenic culprit?: a case report and literature review
Colonic mucosal injury is rare, but may severely fatal, complications following the administration of calcium polystyrene sulfonate resins. The incidence rate is about 0.57%, administered without sorbitol, and increases to 1.8% when it is concomitant with sorbitol, especially in postoperative patien...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Korean Society of Coloproctology
2022-12-01
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| Series: | Annals of Coloproctology |
| Subjects: | |
| Online Access: | http://coloproctol.org/upload/pdf/ac-2021-03-19.pdf |
| _version_ | 1797962744914247680 |
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| author | Setthachai Piwchan Ekawee Sripariwuth Peerayut Sitthichaiyakul |
| author_facet | Setthachai Piwchan Ekawee Sripariwuth Peerayut Sitthichaiyakul |
| author_sort | Setthachai Piwchan |
| collection | DOAJ |
| description | Colonic mucosal injury is rare, but may severely fatal, complications following the administration of calcium polystyrene sulfonate resins. The incidence rate is about 0.57%, administered without sorbitol, and increases to 1.8% when it is concomitant with sorbitol, especially in postoperative patients. In this case report, we demonstrated the case of a 77-year-old female with stage 3b chronic kidney disease presented with in-hospital hematochezia after 3 weeks of calcium polystyrene sulfonate administration. The colonoscopic findings showed several serpiginous ulcers with some oozing at descending and sigmoid colon. The histological findings revealed some focal inflammation and ulcerations with crystal-like materials, compatible with cation exchange resins. The recent in vitro study, explaining the pathogenesis of cation exchange resin-associated colonic mucosal injury, was also reviewed. |
| first_indexed | 2024-04-11T01:17:44Z |
| format | Article |
| id | doaj.art-c44b0fe9f700405c9e97406b535064c0 |
| institution | Directory Open Access Journal |
| issn | 2287-9714 2287-9722 |
| language | English |
| last_indexed | 2024-04-11T01:17:44Z |
| publishDate | 2022-12-01 |
| publisher | Korean Society of Coloproctology |
| record_format | Article |
| series | Annals of Coloproctology |
| spelling | doaj.art-c44b0fe9f700405c9e97406b535064c02023-01-03T23:41:47ZengKorean Society of ColoproctologyAnnals of Coloproctology2287-97142287-97222022-12-0138645345610.3393/ac.2021.03.191808Calcium polystyrene sulfonate associated colonic mucosal injury—innocent bystander or pathogenic culprit?: a case report and literature reviewSetthachai Piwchan0Ekawee Sripariwuth1Peerayut Sitthichaiyakul2 Department of Internal Medicine, Faculty of Medicine, Naresuan University Hospital, Phitsanulok, Thailand Department of Internal Medicine, Faculty of Medicine, Naresuan University Hospital, Phitsanulok, Thailand Department of Pathology, Faculty of Medicine, Naresuan University Hospital, Phitsanulok, ThailandColonic mucosal injury is rare, but may severely fatal, complications following the administration of calcium polystyrene sulfonate resins. The incidence rate is about 0.57%, administered without sorbitol, and increases to 1.8% when it is concomitant with sorbitol, especially in postoperative patients. In this case report, we demonstrated the case of a 77-year-old female with stage 3b chronic kidney disease presented with in-hospital hematochezia after 3 weeks of calcium polystyrene sulfonate administration. The colonoscopic findings showed several serpiginous ulcers with some oozing at descending and sigmoid colon. The histological findings revealed some focal inflammation and ulcerations with crystal-like materials, compatible with cation exchange resins. The recent in vitro study, explaining the pathogenesis of cation exchange resin-associated colonic mucosal injury, was also reviewed.http://coloproctol.org/upload/pdf/ac-2021-03-19.pdfcalcium polystyrene sulfonatecolonic injurycolonic necrosisgastrointestinal hemorrhagekalimate |
| spellingShingle | Setthachai Piwchan Ekawee Sripariwuth Peerayut Sitthichaiyakul Calcium polystyrene sulfonate associated colonic mucosal injury—innocent bystander or pathogenic culprit?: a case report and literature review Annals of Coloproctology calcium polystyrene sulfonate colonic injury colonic necrosis gastrointestinal hemorrhage kalimate |
| title | Calcium polystyrene sulfonate associated colonic mucosal injury—innocent bystander or pathogenic culprit?: a case report and literature review |
| title_full | Calcium polystyrene sulfonate associated colonic mucosal injury—innocent bystander or pathogenic culprit?: a case report and literature review |
| title_fullStr | Calcium polystyrene sulfonate associated colonic mucosal injury—innocent bystander or pathogenic culprit?: a case report and literature review |
| title_full_unstemmed | Calcium polystyrene sulfonate associated colonic mucosal injury—innocent bystander or pathogenic culprit?: a case report and literature review |
| title_short | Calcium polystyrene sulfonate associated colonic mucosal injury—innocent bystander or pathogenic culprit?: a case report and literature review |
| title_sort | calcium polystyrene sulfonate associated colonic mucosal injury innocent bystander or pathogenic culprit a case report and literature review |
| topic | calcium polystyrene sulfonate colonic injury colonic necrosis gastrointestinal hemorrhage kalimate |
| url | http://coloproctol.org/upload/pdf/ac-2021-03-19.pdf |
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