Regulation of Brain-Derived Neurotrophic Factor and Growth Factor Signaling Pathways by Tyrosine Phosphatase Shp2 in the Retina: A Brief Review

Regulation of Brain-Derived Neurotrophic Factor and Growth Factor Signaling Pathways by Tyrosine Phosphatase Shp2 in the Retina: A Brief Review

SH2 domain-containing tyrosine phosphatase-2 (PTPN11 or Shp2) is a ubiquitously expressed protein that plays a key regulatory role in cell proliferation, differentiation and growth factor (GF) signaling. This enzyme is well expressed in various retinal neurons and has emerged as an important player...

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Bibliographic Details
Main Authors: Mojdeh Abbasi, Vivek Gupta, Nitin Chitranshi, Yuyi You, Yogita Dheer, Mehdi Mirzaei, Stuart L. Graham
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Shp2 phosphatase
retina
BDNF neurotrophin
growth factors
TrkB receptor
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2018.00085/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2018.00085/full

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