The potential roles of galectin-3 in AKI and CKD
Acute kidney injury (AKI) is a common condition with high morbidity and mortality, and is associated with the development and progression of chronic kidney disease (CKD). The beta-galactoside binding protein galectin-3 (Gal3), with its proinflammatory and profibrotic properties, has been implicated...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1090724/full |
| _version_ | 1797897181495033856 |
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| author | Fengyun Wang Lixin Zhou Amity Eliaz Chang Hu Xinhua Qiang Li Ke Glenn Chertow Isaac Eliaz Zhiyong Peng Zhiyong Peng |
| author_facet | Fengyun Wang Lixin Zhou Amity Eliaz Chang Hu Xinhua Qiang Li Ke Glenn Chertow Isaac Eliaz Zhiyong Peng Zhiyong Peng |
| author_sort | Fengyun Wang |
| collection | DOAJ |
| description | Acute kidney injury (AKI) is a common condition with high morbidity and mortality, and is associated with the development and progression of chronic kidney disease (CKD). The beta-galactoside binding protein galectin-3 (Gal3), with its proinflammatory and profibrotic properties, has been implicated in the development of both AKI and CKD. Serum Gal3 levels are elevated in patients with AKI and CKD, and elevated Gal3 is associated with progression of CKD. In addition, Gal3 is associated with the incidence of AKI among critically ill patients, and blocking Gal3 in murine models of sepsis and ischemia-reperfusion injury results in significantly lower AKI incidence and mortality. Here we review the role of Gal3 in the pathophysiology of AKI and CKD, as well as the therapeutic potential of targeting Gal3. |
| first_indexed | 2024-04-10T07:53:29Z |
| format | Article |
| id | doaj.art-c44e01a67bf04765abb3a4b89e301c98 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-10T07:53:29Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-c44e01a67bf04765abb3a4b89e301c982023-02-23T07:16:24ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-02-011410.3389/fphys.2023.10907241090724The potential roles of galectin-3 in AKI and CKDFengyun Wang0Lixin Zhou1Amity Eliaz2Chang Hu3Xinhua Qiang4Li Ke5Glenn Chertow6Isaac Eliaz7Zhiyong Peng8Zhiyong Peng9Department of Critical Care Medicine, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, ChinaDepartment of Critical Care Medicine, The First People’s Hospital of Foshan, Foshan, ChinaDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, United StatesDepartment of Critical Care Medicine, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, ChinaDepartment of Critical Care Medicine, The First People’s Hospital of Foshan, Foshan, ChinaDepartment of Critical Care Medicine, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, ChinaDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, United StatesAmitabha Medical Center, Santa Rosa, CA, United StatesDepartment of Critical Care Medicine, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, ChinaCenter of Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, United StatesAcute kidney injury (AKI) is a common condition with high morbidity and mortality, and is associated with the development and progression of chronic kidney disease (CKD). The beta-galactoside binding protein galectin-3 (Gal3), with its proinflammatory and profibrotic properties, has been implicated in the development of both AKI and CKD. Serum Gal3 levels are elevated in patients with AKI and CKD, and elevated Gal3 is associated with progression of CKD. In addition, Gal3 is associated with the incidence of AKI among critically ill patients, and blocking Gal3 in murine models of sepsis and ischemia-reperfusion injury results in significantly lower AKI incidence and mortality. Here we review the role of Gal3 in the pathophysiology of AKI and CKD, as well as the therapeutic potential of targeting Gal3.https://www.frontiersin.org/articles/10.3389/fphys.2023.1090724/fullacute kidney injurychronic kidney diseaseinflammationgalectin-3renal fibrosis |
| spellingShingle | Fengyun Wang Lixin Zhou Amity Eliaz Chang Hu Xinhua Qiang Li Ke Glenn Chertow Isaac Eliaz Zhiyong Peng Zhiyong Peng The potential roles of galectin-3 in AKI and CKD Frontiers in Physiology acute kidney injury chronic kidney disease inflammation galectin-3 renal fibrosis |
| title | The potential roles of galectin-3 in AKI and CKD |
| title_full | The potential roles of galectin-3 in AKI and CKD |
| title_fullStr | The potential roles of galectin-3 in AKI and CKD |
| title_full_unstemmed | The potential roles of galectin-3 in AKI and CKD |
| title_short | The potential roles of galectin-3 in AKI and CKD |
| title_sort | potential roles of galectin 3 in aki and ckd |
| topic | acute kidney injury chronic kidney disease inflammation galectin-3 renal fibrosis |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1090724/full |
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