Global Prevalence of Nosocomial Multidrug-Resistant <i>Klebsiella pneumoniae</i>: A Systematic Review and Meta-Analysis
The emergence of nosocomial multidrug-resistant <i>Klebsiella pneumoniae</i> is an escalating public health threat worldwide. The prevalence of nosocomial infections due to <i>K. pneumoniae</i> was recorded up to 10%. In this systematic review and meta-analysis, which were co...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/10/12/1508 |
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| author | Nur Ain Mohd Asri Suhana Ahmad Rohimah Mohamud Nurmardhiah Mohd Hanafi Nur Fatihah Mohd Zaidi Ahmad Adebayo Irekeola Rafidah Hanim Shueb Leow Chiuan Yee Norhayati Mohd Noor Fatin Hamimi Mustafa Chan Yean Yean Nik Yusnoraini Yusof |
| author_facet | Nur Ain Mohd Asri Suhana Ahmad Rohimah Mohamud Nurmardhiah Mohd Hanafi Nur Fatihah Mohd Zaidi Ahmad Adebayo Irekeola Rafidah Hanim Shueb Leow Chiuan Yee Norhayati Mohd Noor Fatin Hamimi Mustafa Chan Yean Yean Nik Yusnoraini Yusof |
| author_sort | Nur Ain Mohd Asri |
| collection | DOAJ |
| description | The emergence of nosocomial multidrug-resistant <i>Klebsiella pneumoniae</i> is an escalating public health threat worldwide. The prevalence of nosocomial infections due to <i>K. pneumoniae</i> was recorded up to 10%. In this systematic review and meta-analysis, which were conducted according to the guidelines of Preferred Reporting Items for Systematic Review and Meta-Analysis, 1092 articles were screened from four databases of which 47 studies fulfilled the selected criteria. By performing a random-effect model, the pooled prevalence of nosocomial multidrug-resistant <i>K. pneumoniae</i> was estimated at 32.8% (95% CI, 23.6–43.6), with high heterogeneity (I<sup>2</sup> 98.29%, <i>p</i>-value < 0.001). The estimated prevalence of this pathogen and a few related studies were discussed, raising awareness of the spread of multidrug-resistant <i>K. pneumoniae</i> in the healthcare setting. The emergence of nosocomial multidrug-resistant <i>K. pneumoniae</i> is expected to increase globally in the future, and the best treatments for treating and preventing this pathogen should be acknowledged by healthcare staff. |
| first_indexed | 2024-03-10T04:39:56Z |
| format | Article |
| id | doaj.art-c44ecdc07ede43c5b2a5a0aee2624c44 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T04:39:56Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-c44ecdc07ede43c5b2a5a0aee2624c442023-11-23T03:30:57ZengMDPI AGAntibiotics2079-63822021-12-011012150810.3390/antibiotics10121508Global Prevalence of Nosocomial Multidrug-Resistant <i>Klebsiella pneumoniae</i>: A Systematic Review and Meta-AnalysisNur Ain Mohd Asri0Suhana Ahmad1Rohimah Mohamud2Nurmardhiah Mohd Hanafi3Nur Fatihah Mohd Zaidi4Ahmad Adebayo Irekeola5Rafidah Hanim Shueb6Leow Chiuan Yee7Norhayati Mohd Noor8Fatin Hamimi Mustafa9Chan Yean Yean10Nik Yusnoraini Yusof11Health Campus, Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Kubang Kerian 16150, MalaysiaDepartment of Immunology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, MalaysiaDepartment of Immunology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, MalaysiaDepartment of Plant Sciences, Kuliyyah of Science, International Islamic University Malaysia, Kuantan 25200, MalaysiaHealth Campus, Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Kubang Kerian 16150, MalaysiaDepartment of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, MalaysiaDepartment of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, MalaysiaSchool of Pharmaceutical Sciences, Universiti Sains Malaysia, Glugor 11800, MalaysiaDepartment of Family Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, MalaysiaHealth Campus, Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Kubang Kerian 16150, MalaysiaHealth Campus, Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Kubang Kerian 16150, MalaysiaHealth Campus, Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Kubang Kerian 16150, MalaysiaThe emergence of nosocomial multidrug-resistant <i>Klebsiella pneumoniae</i> is an escalating public health threat worldwide. The prevalence of nosocomial infections due to <i>K. pneumoniae</i> was recorded up to 10%. In this systematic review and meta-analysis, which were conducted according to the guidelines of Preferred Reporting Items for Systematic Review and Meta-Analysis, 1092 articles were screened from four databases of which 47 studies fulfilled the selected criteria. By performing a random-effect model, the pooled prevalence of nosocomial multidrug-resistant <i>K. pneumoniae</i> was estimated at 32.8% (95% CI, 23.6–43.6), with high heterogeneity (I<sup>2</sup> 98.29%, <i>p</i>-value < 0.001). The estimated prevalence of this pathogen and a few related studies were discussed, raising awareness of the spread of multidrug-resistant <i>K. pneumoniae</i> in the healthcare setting. The emergence of nosocomial multidrug-resistant <i>K. pneumoniae</i> is expected to increase globally in the future, and the best treatments for treating and preventing this pathogen should be acknowledged by healthcare staff.https://www.mdpi.com/2079-6382/10/12/1508worldwideprevalencenosocomialmultidrug-resistant<i>Klebsiella pneumoniae</i>antibiotic resistance |
| spellingShingle | Nur Ain Mohd Asri Suhana Ahmad Rohimah Mohamud Nurmardhiah Mohd Hanafi Nur Fatihah Mohd Zaidi Ahmad Adebayo Irekeola Rafidah Hanim Shueb Leow Chiuan Yee Norhayati Mohd Noor Fatin Hamimi Mustafa Chan Yean Yean Nik Yusnoraini Yusof Global Prevalence of Nosocomial Multidrug-Resistant <i>Klebsiella pneumoniae</i>: A Systematic Review and Meta-Analysis Antibiotics worldwide prevalence nosocomial multidrug-resistant <i>Klebsiella pneumoniae</i> antibiotic resistance |
| title | Global Prevalence of Nosocomial Multidrug-Resistant <i>Klebsiella pneumoniae</i>: A Systematic Review and Meta-Analysis |
| title_full | Global Prevalence of Nosocomial Multidrug-Resistant <i>Klebsiella pneumoniae</i>: A Systematic Review and Meta-Analysis |
| title_fullStr | Global Prevalence of Nosocomial Multidrug-Resistant <i>Klebsiella pneumoniae</i>: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Global Prevalence of Nosocomial Multidrug-Resistant <i>Klebsiella pneumoniae</i>: A Systematic Review and Meta-Analysis |
| title_short | Global Prevalence of Nosocomial Multidrug-Resistant <i>Klebsiella pneumoniae</i>: A Systematic Review and Meta-Analysis |
| title_sort | global prevalence of nosocomial multidrug resistant i klebsiella pneumoniae i a systematic review and meta analysis |
| topic | worldwide prevalence nosocomial multidrug-resistant <i>Klebsiella pneumoniae</i> antibiotic resistance |
| url | https://www.mdpi.com/2079-6382/10/12/1508 |
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