Glucose Metabolism, Neural Cell Senescence and Alzheimer’s Disease
Alzheimer’s disease (AD), an elderly neurodegenerative disorder with a high incidence and progressive memory decline, is one of the most expensive, lethal, and burdening diseases. To date, the pathogenesis of AD has not been fully illustrated. Emerging studies have revealed that cellular senescence...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/8/4351 |
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| author | Qianqian Wang Linyan Duan Xingfan Li Yifu Wang Wenna Guo Fangxia Guan Shanshan Ma |
| author_facet | Qianqian Wang Linyan Duan Xingfan Li Yifu Wang Wenna Guo Fangxia Guan Shanshan Ma |
| author_sort | Qianqian Wang |
| collection | DOAJ |
| description | Alzheimer’s disease (AD), an elderly neurodegenerative disorder with a high incidence and progressive memory decline, is one of the most expensive, lethal, and burdening diseases. To date, the pathogenesis of AD has not been fully illustrated. Emerging studies have revealed that cellular senescence and abnormal glucose metabolism in the brain are the early hallmarks of AD. Moreover, cellular senescence and glucose metabolism disturbance in the brain of AD patients may precede amyloid-β deposition or Tau protein phosphorylation. Thus, metabolic reprogramming targeting senescent microglia and astrocytes may be a novel strategy for AD intervention and treatment. Here, we recapitulate the relationships between neural cell senescence and abnormal glucose metabolism (e.g., insulin signaling, glucose and lactate metabolism) in AD. We then discuss the potential perspective of metabolic reprogramming towards an AD intervention, providing a theoretical basis for the further exploration of the pathogenesis of and therapeutic approach toward AD. |
| first_indexed | 2024-03-09T13:32:28Z |
| format | Article |
| id | doaj.art-c44ef310a4634109a6660c611c959cf2 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T13:32:28Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c44ef310a4634109a6660c611c959cf22023-11-30T21:16:05ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-04-01238435110.3390/ijms23084351Glucose Metabolism, Neural Cell Senescence and Alzheimer’s DiseaseQianqian Wang0Linyan Duan1Xingfan Li2Yifu Wang3Wenna Guo4Fangxia Guan5Shanshan Ma6School of Life Sciences, Zhengzhou University, Zhengzhou 450001, ChinaSchool of Life Sciences, Zhengzhou University, Zhengzhou 450001, ChinaSchool of Life Sciences, Zhengzhou University, Zhengzhou 450001, ChinaSchool of Life Sciences, Zhengzhou University, Zhengzhou 450001, ChinaSchool of Life Sciences, Zhengzhou University, Zhengzhou 450001, ChinaSchool of Life Sciences, Zhengzhou University, Zhengzhou 450001, ChinaSchool of Life Sciences, Zhengzhou University, Zhengzhou 450001, ChinaAlzheimer’s disease (AD), an elderly neurodegenerative disorder with a high incidence and progressive memory decline, is one of the most expensive, lethal, and burdening diseases. To date, the pathogenesis of AD has not been fully illustrated. Emerging studies have revealed that cellular senescence and abnormal glucose metabolism in the brain are the early hallmarks of AD. Moreover, cellular senescence and glucose metabolism disturbance in the brain of AD patients may precede amyloid-β deposition or Tau protein phosphorylation. Thus, metabolic reprogramming targeting senescent microglia and astrocytes may be a novel strategy for AD intervention and treatment. Here, we recapitulate the relationships between neural cell senescence and abnormal glucose metabolism (e.g., insulin signaling, glucose and lactate metabolism) in AD. We then discuss the potential perspective of metabolic reprogramming towards an AD intervention, providing a theoretical basis for the further exploration of the pathogenesis of and therapeutic approach toward AD.https://www.mdpi.com/1422-0067/23/8/4351glucose metabolismneural cell senescenceAlzheimer’s diseasemetabolic reprogrammingtherapeutics |
| spellingShingle | Qianqian Wang Linyan Duan Xingfan Li Yifu Wang Wenna Guo Fangxia Guan Shanshan Ma Glucose Metabolism, Neural Cell Senescence and Alzheimer’s Disease International Journal of Molecular Sciences glucose metabolism neural cell senescence Alzheimer’s disease metabolic reprogramming therapeutics |
| title | Glucose Metabolism, Neural Cell Senescence and Alzheimer’s Disease |
| title_full | Glucose Metabolism, Neural Cell Senescence and Alzheimer’s Disease |
| title_fullStr | Glucose Metabolism, Neural Cell Senescence and Alzheimer’s Disease |
| title_full_unstemmed | Glucose Metabolism, Neural Cell Senescence and Alzheimer’s Disease |
| title_short | Glucose Metabolism, Neural Cell Senescence and Alzheimer’s Disease |
| title_sort | glucose metabolism neural cell senescence and alzheimer s disease |
| topic | glucose metabolism neural cell senescence Alzheimer’s disease metabolic reprogramming therapeutics |
| url | https://www.mdpi.com/1422-0067/23/8/4351 |
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