Mitochondrial antiviral signaling protein: a potential therapeutic target in renal disease
Mitochondrial antiviral signaling protein (MAVS) is a key innate immune adaptor on the outer mitochondrial membrane that acts as a switch in the immune signal transduction response to viral infections. Some studies have reported that MAVS mediates NF-κB and type I interferon signaling during viral i...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1266461/full |
| _version_ | 1797660943789850624 |
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| author | Meng Wu Zhiyin Pei Guangfeng Long Hongbing Chen Zhanjun Jia Zhanjun Jia Weiwei Xia Weiwei Xia Weiwei Xia |
| author_facet | Meng Wu Zhiyin Pei Guangfeng Long Hongbing Chen Zhanjun Jia Zhanjun Jia Weiwei Xia Weiwei Xia Weiwei Xia |
| author_sort | Meng Wu |
| collection | DOAJ |
| description | Mitochondrial antiviral signaling protein (MAVS) is a key innate immune adaptor on the outer mitochondrial membrane that acts as a switch in the immune signal transduction response to viral infections. Some studies have reported that MAVS mediates NF-κB and type I interferon signaling during viral infection and is also required for optimal NLRP3 inflammasome activity. Recent studies have reported that MAVS is involved in various cancers, systemic lupus erythematosus, kidney diseases, and cardiovascular diseases. Herein, we summarize the structure, activation, pathophysiological roles, and MAVS-based therapies for renal diseases. This review provides novel insights into MAVS’s role and therapeutic potential in the pathogenesis of renal diseases. |
| first_indexed | 2024-03-11T18:37:12Z |
| format | Article |
| id | doaj.art-c44f1676587e4f9fa33e6082f1847d2e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-11T18:37:12Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-c44f1676587e4f9fa33e6082f1847d2e2023-10-12T16:43:58ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-10-011410.3389/fimmu.2023.12664611266461Mitochondrial antiviral signaling protein: a potential therapeutic target in renal diseaseMeng Wu0Zhiyin Pei1Guangfeng Long2Hongbing Chen3Zhanjun Jia4Zhanjun Jia5Weiwei Xia6Weiwei Xia7Weiwei Xia8Department of Clinical Laboratory, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Clinical Laboratory, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Clinical Laboratory, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Clinical Laboratory, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Nephrology, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaJiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, ChinaDepartment of Clinical Laboratory, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Nephrology, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaJiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, ChinaMitochondrial antiviral signaling protein (MAVS) is a key innate immune adaptor on the outer mitochondrial membrane that acts as a switch in the immune signal transduction response to viral infections. Some studies have reported that MAVS mediates NF-κB and type I interferon signaling during viral infection and is also required for optimal NLRP3 inflammasome activity. Recent studies have reported that MAVS is involved in various cancers, systemic lupus erythematosus, kidney diseases, and cardiovascular diseases. Herein, we summarize the structure, activation, pathophysiological roles, and MAVS-based therapies for renal diseases. This review provides novel insights into MAVS’s role and therapeutic potential in the pathogenesis of renal diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1266461/fullMAVSrenal diseaseinnate immuneNLRP3inflammation |
| spellingShingle | Meng Wu Zhiyin Pei Guangfeng Long Hongbing Chen Zhanjun Jia Zhanjun Jia Weiwei Xia Weiwei Xia Weiwei Xia Mitochondrial antiviral signaling protein: a potential therapeutic target in renal disease Frontiers in Immunology MAVS renal disease innate immune NLRP3 inflammation |
| title | Mitochondrial antiviral signaling protein: a potential therapeutic target in renal disease |
| title_full | Mitochondrial antiviral signaling protein: a potential therapeutic target in renal disease |
| title_fullStr | Mitochondrial antiviral signaling protein: a potential therapeutic target in renal disease |
| title_full_unstemmed | Mitochondrial antiviral signaling protein: a potential therapeutic target in renal disease |
| title_short | Mitochondrial antiviral signaling protein: a potential therapeutic target in renal disease |
| title_sort | mitochondrial antiviral signaling protein a potential therapeutic target in renal disease |
| topic | MAVS renal disease innate immune NLRP3 inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1266461/full |
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