A hierarchical and collaborative BRD4/CEBPD partnership governs vascular smooth muscle cell inflammation

A hierarchical and collaborative BRD4/CEBPD partnership governs vascular smooth muscle cell inflammation

Bromodomain protein BRD4 reads histone acetylation (H3K27ac), an epigenomic mark of transcription enhancers. CCAAT enhancer binding protein delta (CEBPD) is a transcription factor typically studied in metabolism. While both are potent effectors and potential therapeutic targets, their relationship w...

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Bibliographic Details
Main Authors: Qingwei Wang, Hatice Gulcin Ozer, Bowen Wang, Mengxue Zhang, Go Urabe, Yitao Huang, K. Craig Kent, Lian-Wang Guo
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
BRD4
CEBPD
ChIP sequencing
vascular smooth muscle cell state transition
Online Access:http://www.sciencedirect.com/science/article/pii/S232905012100036X

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