A CZT-based blood counter for quantitative molecular imaging
Abstract Background Robust quantitative analysis in positron emission tomography (PET) and in single-photon emission computed tomography (SPECT) typically requires the time-activity curve as an input function for the pharmacokinetic modeling of tracer uptake. For this purpose, a new automated tool f...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2017-06-01
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| Series: | EJNMMI Physics |
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| Online Access: | http://link.springer.com/article/10.1186/s40658-017-0184-5 |
| _version_ | 1830483974055526400 |
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| author | Romain Espagnet Andrea Frezza Jean-Pierre Martin Louis-André Hamel Laëtitia Lechippey Jean-Mathieu Beauregard Philippe Després |
| author_facet | Romain Espagnet Andrea Frezza Jean-Pierre Martin Louis-André Hamel Laëtitia Lechippey Jean-Mathieu Beauregard Philippe Després |
| author_sort | Romain Espagnet |
| collection | DOAJ |
| description | Abstract Background Robust quantitative analysis in positron emission tomography (PET) and in single-photon emission computed tomography (SPECT) typically requires the time-activity curve as an input function for the pharmacokinetic modeling of tracer uptake. For this purpose, a new automated tool for the determination of blood activity as a function of time is presented. The device, compact enough to be used on the patient bed, relies on a peristaltic pump for continuous blood withdrawal at user-defined rates. Gamma detection is based on a 20 × 20 × 15 mm3 cadmium zinc telluride (CZT) detector, read by custom-made electronics and a field-programmable gate array-based signal processing unit. A graphical user interface (GUI) allows users to select parameters and easily perform acquisitions. Results This paper presents the overall design of the device as well as the results related to the detector performance in terms of stability, sensitivity and energy resolution. Results from a patient study are also reported. The device achieved a sensitivity of 7.1 cps/(kBq/mL) and a minimum detectable activity of 2.5 kBq/ml for 18F. The gamma counter also demonstrated an excellent stability with a deviation in count rates inferior to 0.05% over 6 h. An energy resolution of 8% was achieved at 662 keV. Conclusions The patient study was conclusive and demonstrated that the compact gamma blood counter developed has the sensitivity and the stability required to conduct quantitative molecular imaging studies in PET and SPECT. |
| first_indexed | 2024-12-21T18:00:36Z |
| format | Article |
| id | doaj.art-c4515f071f1d4c88b94790bd2007e3b2 |
| institution | Directory Open Access Journal |
| issn | 2197-7364 |
| language | English |
| last_indexed | 2024-12-21T18:00:36Z |
| publishDate | 2017-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Physics |
| spelling | doaj.art-c4515f071f1d4c88b94790bd2007e3b22022-12-21T18:55:04ZengSpringerOpenEJNMMI Physics2197-73642017-06-014111610.1186/s40658-017-0184-5A CZT-based blood counter for quantitative molecular imagingRomain Espagnet0Andrea Frezza1Jean-Pierre Martin2Louis-André Hamel3Laëtitia Lechippey4Jean-Mathieu Beauregard5Philippe Després6Department of Physics, Engineering Physics and Optics and Cancer Research Center, Université LavalDepartment of Physics, Engineering Physics and Optics and Cancer Research Center, Université LavalDepartment of Physics, Université de MontréalDepartment of Physics, Université de MontréalDepartment of Physics, Engineering Physics and Optics and Cancer Research Center, Université LavalDepartment of Medical Imaging and Research Center of CHU de Québec - Université LavalDepartment of Physics, Engineering Physics and Optics and Cancer Research Center, Université LavalAbstract Background Robust quantitative analysis in positron emission tomography (PET) and in single-photon emission computed tomography (SPECT) typically requires the time-activity curve as an input function for the pharmacokinetic modeling of tracer uptake. For this purpose, a new automated tool for the determination of blood activity as a function of time is presented. The device, compact enough to be used on the patient bed, relies on a peristaltic pump for continuous blood withdrawal at user-defined rates. Gamma detection is based on a 20 × 20 × 15 mm3 cadmium zinc telluride (CZT) detector, read by custom-made electronics and a field-programmable gate array-based signal processing unit. A graphical user interface (GUI) allows users to select parameters and easily perform acquisitions. Results This paper presents the overall design of the device as well as the results related to the detector performance in terms of stability, sensitivity and energy resolution. Results from a patient study are also reported. The device achieved a sensitivity of 7.1 cps/(kBq/mL) and a minimum detectable activity of 2.5 kBq/ml for 18F. The gamma counter also demonstrated an excellent stability with a deviation in count rates inferior to 0.05% over 6 h. An energy resolution of 8% was achieved at 662 keV. Conclusions The patient study was conclusive and demonstrated that the compact gamma blood counter developed has the sensitivity and the stability required to conduct quantitative molecular imaging studies in PET and SPECT.http://link.springer.com/article/10.1186/s40658-017-0184-5CZTGamma counterBlood activityMolecular imagingPET scanTAC |
| spellingShingle | Romain Espagnet Andrea Frezza Jean-Pierre Martin Louis-André Hamel Laëtitia Lechippey Jean-Mathieu Beauregard Philippe Després A CZT-based blood counter for quantitative molecular imaging EJNMMI Physics CZT Gamma counter Blood activity Molecular imaging PET scan TAC |
| title | A CZT-based blood counter for quantitative molecular imaging |
| title_full | A CZT-based blood counter for quantitative molecular imaging |
| title_fullStr | A CZT-based blood counter for quantitative molecular imaging |
| title_full_unstemmed | A CZT-based blood counter for quantitative molecular imaging |
| title_short | A CZT-based blood counter for quantitative molecular imaging |
| title_sort | czt based blood counter for quantitative molecular imaging |
| topic | CZT Gamma counter Blood activity Molecular imaging PET scan TAC |
| url | http://link.springer.com/article/10.1186/s40658-017-0184-5 |
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