Curcumin Mitigates Neuro-Inflammation by Modulating Microglia Polarization Through Inhibiting TLR4 Axis Signaling Pathway Following Experimental Subarachnoid Hemorrhage

Curcumin Mitigates Neuro-Inflammation by Modulating Microglia Polarization Through Inhibiting TLR4 Axis Signaling Pathway Following Experimental Subarachnoid Hemorrhage

Subarachnoid hemorrhage (SAH) elicits destruction of neuronal cells and neurological function, which is exacerbated by neuro-inflammation in EBI, and toll-like receptor 4 (TLR4) plays an important role in inflammatory cascade via modulation microglia polarization. Curcumin (Cur), as a natural phytoc...

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Bibliographic Details
Main Authors: YongYue Gao, Zong Zhuang, Yue Lu, Tao Tao, Yan Zhou, GuangJie Liu, Han Wang, DingDing Zhang, LingYun Wu, HaiBin Dai, Wei Li, ChunHua Hang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Neuroscience
Subjects:
toll-like receptor 4
subarachnoid hemorrhage
curcumin
neuro-inflammation
microglia polarization
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.01223/full

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