Seroepidemiological and Molecular Survey for the Detection of SARS-CoV-2 Infection among Children in Iran, September 2020 to June 2021: 1-Year Cross-Sectional Study
A population-based seroepidemiological and molecular survey on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was performed to detect induced antibodies to prior exposure and active infection of children aged 14 years or less in Tehran between 19 September 2020 and 21 June 2021. Moreov...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/11/7/1672 |
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| author | Roxana Mansour Ghanaie Idesbald Boone Ahmad Reza Shamshiri Abdollah Karimi Arezu Amirali Noushin Marhamati Mohammad Hossein Rostami Niloofar Pashaei Shahriar Janbazi Leila Azimi Hannan Khodaei Fatemeh Fallah Tim Eckmanns Andreas Jansen Hamid Reza Baradaran Maryam Momeny Ourimi Saeed Maham Ameneh Elikaei Masoud Alebouyeh |
| author_facet | Roxana Mansour Ghanaie Idesbald Boone Ahmad Reza Shamshiri Abdollah Karimi Arezu Amirali Noushin Marhamati Mohammad Hossein Rostami Niloofar Pashaei Shahriar Janbazi Leila Azimi Hannan Khodaei Fatemeh Fallah Tim Eckmanns Andreas Jansen Hamid Reza Baradaran Maryam Momeny Ourimi Saeed Maham Ameneh Elikaei Masoud Alebouyeh |
| author_sort | Roxana Mansour Ghanaie |
| collection | DOAJ |
| description | A population-based seroepidemiological and molecular survey on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was performed to detect induced antibodies to prior exposure and active infection of children aged 14 years or less in Tehran between 19 September 2020 and 21 June 2021. Moreover, correlations between the children’s demographic data and coronavirus disease 2019 (COVID-19) symptoms with the infection status were investigated. Out of 1517 participants, cardinal symptoms of COVID-19 (fever > 38 °C and/or cough and/or diarrhea) were detected in 18%, and serological history of SARS-CoV-2 infection and polymerase chain reaction (PCR) positivity were confirmed in 33.2% and 10.7% of the weighted population, respectively. The prevalence of SARS-CoV-2 infection was significantly higher among 10–14-year-old children. Active infection was significantly higher in symptomatic children and during autumn 2020 and spring 2021. The quantitative reverse transcription real-time PCR (RT-qPCR) positivity was significantly higher among families with a lower socioeconomic status, whereas no association between RT-qPCR or seropositivity was determined with household size, underlying diseases, or gender. In conclusion, high SARS-CoV-2 infection prevalence and seroprevalence were detected in children in Tehran in different seasons. Infection prevalence was significantly higher in older children and in those with a positive history of close contact with infected cases and/or lower socioeconomic status. |
| first_indexed | 2024-03-11T00:49:12Z |
| format | Article |
| id | doaj.art-c4537199168842eea406ec846169640a |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-11T00:49:12Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-c4537199168842eea406ec846169640a2023-11-18T20:34:49ZengMDPI AGMicroorganisms2076-26072023-06-01117167210.3390/microorganisms11071672Seroepidemiological and Molecular Survey for the Detection of SARS-CoV-2 Infection among Children in Iran, September 2020 to June 2021: 1-Year Cross-Sectional StudyRoxana Mansour Ghanaie0Idesbald Boone1Ahmad Reza Shamshiri2Abdollah Karimi3Arezu Amirali4Noushin Marhamati5Mohammad Hossein Rostami6Niloofar Pashaei7Shahriar Janbazi8Leila Azimi9Hannan Khodaei10Fatemeh Fallah11Tim Eckmanns12Andreas Jansen13Hamid Reza Baradaran14Maryam Momeny Ourimi15Saeed Maham16Ameneh Elikaei17Masoud Alebouyeh18Pediatric Infections Research Centre, Research Institute for Children’s Health, Shahid Beheshti University of Medical Sciences, Tehran 1546815514, IranDepartment of Infectious Disease Epidemiology, Robert Koch Institute, 13353 Berlin, GermanyResearch Center for Caries Prevention, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran 1439955934, IranPediatric Infections Research Centre, Research Institute for Children’s Health, Shahid Beheshti University of Medical Sciences, Tehran 1546815514, IranPediatric Infections Research Centre, Research Institute for Children’s Health, Shahid Beheshti University of Medical Sciences, Tehran 1546815514, IranPediatric Infections Research Centre, Research Institute for Children’s Health, Shahid Beheshti University of Medical Sciences, Tehran 1546815514, IranSnapp Group (Iran Internet Group), Tehran 1987913151, IranCentral Laboratory, Deputy of Public Health, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, IranDepartment of Health and Medical Medicine, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 1983969411, IranPediatric Infections Research Centre, Research Institute for Children’s Health, Shahid Beheshti University of Medical Sciences, Tehran 1546815514, IranPediatric Infections Research Centre, Research Institute for Children’s Health, Shahid Beheshti University of Medical Sciences, Tehran 1546815514, IranPediatric Infections Research Centre, Research Institute for Children’s Health, Shahid Beheshti University of Medical Sciences, Tehran 1546815514, IranDepartment of Infectious Disease Epidemiology, Robert Koch Institute, 13353 Berlin, GermanyCentre for International Health Protection, Robert Koch Institute, 13353 Berlin, GermanyDepartment of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran 1449614535, IranMofid Children’s Hospital, Shahid Beheshti University of Medical Sciences, Tehran 1546815514, IranPediatric Infections Research Centre, Research Institute for Children’s Health, Shahid Beheshti University of Medical Sciences, Tehran 1546815514, IranDepartment of Microbiology, Faculty of Biological Sciences, Alzahra University, Tehran 1993893973, IranPediatric Infections Research Centre, Research Institute for Children’s Health, Shahid Beheshti University of Medical Sciences, Tehran 1546815514, IranA population-based seroepidemiological and molecular survey on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was performed to detect induced antibodies to prior exposure and active infection of children aged 14 years or less in Tehran between 19 September 2020 and 21 June 2021. Moreover, correlations between the children’s demographic data and coronavirus disease 2019 (COVID-19) symptoms with the infection status were investigated. Out of 1517 participants, cardinal symptoms of COVID-19 (fever > 38 °C and/or cough and/or diarrhea) were detected in 18%, and serological history of SARS-CoV-2 infection and polymerase chain reaction (PCR) positivity were confirmed in 33.2% and 10.7% of the weighted population, respectively. The prevalence of SARS-CoV-2 infection was significantly higher among 10–14-year-old children. Active infection was significantly higher in symptomatic children and during autumn 2020 and spring 2021. The quantitative reverse transcription real-time PCR (RT-qPCR) positivity was significantly higher among families with a lower socioeconomic status, whereas no association between RT-qPCR or seropositivity was determined with household size, underlying diseases, or gender. In conclusion, high SARS-CoV-2 infection prevalence and seroprevalence were detected in children in Tehran in different seasons. Infection prevalence was significantly higher in older children and in those with a positive history of close contact with infected cases and/or lower socioeconomic status.https://www.mdpi.com/2076-2607/11/7/1672SARS-CoV-2COVID-19childrenseroprevalenceRT-qPCRIran |
| spellingShingle | Roxana Mansour Ghanaie Idesbald Boone Ahmad Reza Shamshiri Abdollah Karimi Arezu Amirali Noushin Marhamati Mohammad Hossein Rostami Niloofar Pashaei Shahriar Janbazi Leila Azimi Hannan Khodaei Fatemeh Fallah Tim Eckmanns Andreas Jansen Hamid Reza Baradaran Maryam Momeny Ourimi Saeed Maham Ameneh Elikaei Masoud Alebouyeh Seroepidemiological and Molecular Survey for the Detection of SARS-CoV-2 Infection among Children in Iran, September 2020 to June 2021: 1-Year Cross-Sectional Study Microorganisms SARS-CoV-2 COVID-19 children seroprevalence RT-qPCR Iran |
| title | Seroepidemiological and Molecular Survey for the Detection of SARS-CoV-2 Infection among Children in Iran, September 2020 to June 2021: 1-Year Cross-Sectional Study |
| title_full | Seroepidemiological and Molecular Survey for the Detection of SARS-CoV-2 Infection among Children in Iran, September 2020 to June 2021: 1-Year Cross-Sectional Study |
| title_fullStr | Seroepidemiological and Molecular Survey for the Detection of SARS-CoV-2 Infection among Children in Iran, September 2020 to June 2021: 1-Year Cross-Sectional Study |
| title_full_unstemmed | Seroepidemiological and Molecular Survey for the Detection of SARS-CoV-2 Infection among Children in Iran, September 2020 to June 2021: 1-Year Cross-Sectional Study |
| title_short | Seroepidemiological and Molecular Survey for the Detection of SARS-CoV-2 Infection among Children in Iran, September 2020 to June 2021: 1-Year Cross-Sectional Study |
| title_sort | seroepidemiological and molecular survey for the detection of sars cov 2 infection among children in iran september 2020 to june 2021 1 year cross sectional study |
| topic | SARS-CoV-2 COVID-19 children seroprevalence RT-qPCR Iran |
| url | https://www.mdpi.com/2076-2607/11/7/1672 |
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