In vivo compartmental kinetics of Plasmodium falciparum histidine-rich protein II in the blood of humans and in BALB/c mice infected with a transgenic Plasmodium berghei parasite expressing histidine-rich protein II

In vivo compartmental kinetics of Plasmodium falciparum histidine-rich protein II in the blood of humans and in BALB/c mice infected with a transgenic Plasmodium berghei parasite expressing histidine-rich protein II

Abstract Background The Plasmodium falciparum histidine-rich protein II (PfHRP2) is a common biomarker used in malaria rapid diagnostic tests (RDTs), but can persist in the blood for up to 40 days following curative treatment. The persistence of PfHRP2 presents a false positive limitation to diagnos...

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Bibliographic Details
Main Authors: Kristin E. Poti, Amanda E. Balaban, Priya Pal, Tamaki Kobayashi, Daniel E. Goldberg, Photini Sinnis, David J. Sullivan
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Malaria Journal
Subjects:
Malaria
Histidine-rich protein II
HRP2
Persistence
Once-infected RBCs
Erythrocyte pitting
Online Access:http://link.springer.com/article/10.1186/s12936-019-2712-3

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http://link.springer.com/article/10.1186/s12936-019-2712-3

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