Sustained-Release Solid Dispersion of High-Melting-Point and Insoluble Resveratrol Prepared through Hot Melt Extrusion to Improve Its Solubility and Bioavailability

Sustained-Release Solid Dispersion of High-Melting-Point and Insoluble Resveratrol Prepared through Hot Melt Extrusion to Improve Its Solubility and Bioavailability

This study aimed to prepare a sustained-release solid dispersion of poorly water-soluble resveratrol (RES) with high melting point in a single hot melt extrusion step. A hydrophobic–hydrophilic polymeric blend (Eudragit RS and PEG6000) was used to control the release of RES. With the dispersive mixi...

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Bibliographic Details
Main Authors: Wenjing Zhu, Wenling Fan, Xiaotong Zhang, Meiqi Gao
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Molecules
Subjects:
solid dispersion
resveratrol
hot melt extrusion
dissolution
sustained-release
Online Access:https://www.mdpi.com/1420-3049/26/16/4982

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