Fatty liver-induced changes in stereotypic behavior in rats and effects of glucagon-like peptide-1 analog on stereotypy
Although understanding the relation between psychotic behavior and immune abnormalities has been the focus of research for many years, it remains to be elucidated whether the changes in cytokine levels are part of etiology or a result of the stress associated with the disorder. In accordance with pr...
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| Format: | Article |
| Language: | English |
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Wiley
2014-09-01
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| Series: | Kaohsiung Journal of Medical Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1607551X14001399 |
| _version_ | 1819112620696797184 |
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| author | Oytun Erbaş Hüseyin Serdar Akseki Volkan Solmaz Hüseyin Aktuğ Dilek Taşkıran |
| author_facet | Oytun Erbaş Hüseyin Serdar Akseki Volkan Solmaz Hüseyin Aktuğ Dilek Taşkıran |
| author_sort | Oytun Erbaş |
| collection | DOAJ |
| description | Although understanding the relation between psychotic behavior and immune abnormalities has been the focus of research for many years, it remains to be elucidated whether the changes in cytokine levels are part of etiology or a result of the stress associated with the disorder. In accordance with previous studies on changes in cytokine levels due to metabolic changes and psychosis, we hypothesized that fatty liver may potentiate apomorphine-induced stereotypy in a rodent model and that a synthetic glucagon-like peptide-1 analog exenatide would ameliorate this effect. In this study, 18 male Sprague Dawley albino mature rats were used. We induced hepatosteatosis in these rats by feeding them with 30% fructose dissolved in drinking water for 8 weeks. The animals were divided into three groups, namely, the normal group, the intracerebroventricular (ICV) exenatide group, and the ICV NaCl group. Apomorphine-induced stereotypic behavior test was performed in all groups and the liver was removed for histopathological examination after all the rats were euthanized. In the nonalcoholic fatty liver (NAFL) group, stereotypy scores were significantly increased compared with the control group rats (p < 0.00001). A significant decrease in stereotypy scores were observed in the ICV exenatide group with NAFL when compared with the ICV saline group with NAFL (p < 0.005). In addition, brain malondialdehyde and tumor necrosis factor-α levels decreased in the ICV exenatide group. The results of this study showed that fatty liver enhances the effect of apomorphine on stereotypy, which was reversed by exenatide possibly by antioxidant and anti-inflammatory effects. |
| first_indexed | 2024-12-22T04:16:24Z |
| format | Article |
| id | doaj.art-c45983615335450bb072ec0832829718 |
| institution | Directory Open Access Journal |
| issn | 1607-551X |
| language | English |
| last_indexed | 2024-12-22T04:16:24Z |
| publishDate | 2014-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Kaohsiung Journal of Medical Sciences |
| spelling | doaj.art-c45983615335450bb072ec08328297182022-12-21T18:39:24ZengWileyKaohsiung Journal of Medical Sciences1607-551X2014-09-0130944745210.1016/j.kjms.2014.05.007Fatty liver-induced changes in stereotypic behavior in rats and effects of glucagon-like peptide-1 analog on stereotypyOytun Erbaş0Hüseyin Serdar Akseki1Volkan Solmaz2Hüseyin Aktuğ3Dilek Taşkıran4Department of Physiology, Faculty of Medicine, Gaziosmanpaşa University, Tokat, TurkeyDepartment of Psychiatry, Tavşanlı State Hospital, Kütahya, TurkeyDepartment of Neurology, Faculty of Medicine, Gaziosmanpaşa University, Tokat, TurkeyDepartment of Histology and Embryology, School of Medicine, Ege University, Izmir, TurkeyDepartment of Physiology, School of Medicine, Ege University, Izmir, TurkeyAlthough understanding the relation between psychotic behavior and immune abnormalities has been the focus of research for many years, it remains to be elucidated whether the changes in cytokine levels are part of etiology or a result of the stress associated with the disorder. In accordance with previous studies on changes in cytokine levels due to metabolic changes and psychosis, we hypothesized that fatty liver may potentiate apomorphine-induced stereotypy in a rodent model and that a synthetic glucagon-like peptide-1 analog exenatide would ameliorate this effect. In this study, 18 male Sprague Dawley albino mature rats were used. We induced hepatosteatosis in these rats by feeding them with 30% fructose dissolved in drinking water for 8 weeks. The animals were divided into three groups, namely, the normal group, the intracerebroventricular (ICV) exenatide group, and the ICV NaCl group. Apomorphine-induced stereotypic behavior test was performed in all groups and the liver was removed for histopathological examination after all the rats were euthanized. In the nonalcoholic fatty liver (NAFL) group, stereotypy scores were significantly increased compared with the control group rats (p < 0.00001). A significant decrease in stereotypy scores were observed in the ICV exenatide group with NAFL when compared with the ICV saline group with NAFL (p < 0.005). In addition, brain malondialdehyde and tumor necrosis factor-α levels decreased in the ICV exenatide group. The results of this study showed that fatty liver enhances the effect of apomorphine on stereotypy, which was reversed by exenatide possibly by antioxidant and anti-inflammatory effects.http://www.sciencedirect.com/science/article/pii/S1607551X14001399Apomorphine-induced stereotypic behavior testExenatideNonalcoholic fatty liverPsychosis |
| spellingShingle | Oytun Erbaş Hüseyin Serdar Akseki Volkan Solmaz Hüseyin Aktuğ Dilek Taşkıran Fatty liver-induced changes in stereotypic behavior in rats and effects of glucagon-like peptide-1 analog on stereotypy Kaohsiung Journal of Medical Sciences Apomorphine-induced stereotypic behavior test Exenatide Nonalcoholic fatty liver Psychosis |
| title | Fatty liver-induced changes in stereotypic behavior in rats and effects of glucagon-like peptide-1 analog on stereotypy |
| title_full | Fatty liver-induced changes in stereotypic behavior in rats and effects of glucagon-like peptide-1 analog on stereotypy |
| title_fullStr | Fatty liver-induced changes in stereotypic behavior in rats and effects of glucagon-like peptide-1 analog on stereotypy |
| title_full_unstemmed | Fatty liver-induced changes in stereotypic behavior in rats and effects of glucagon-like peptide-1 analog on stereotypy |
| title_short | Fatty liver-induced changes in stereotypic behavior in rats and effects of glucagon-like peptide-1 analog on stereotypy |
| title_sort | fatty liver induced changes in stereotypic behavior in rats and effects of glucagon like peptide 1 analog on stereotypy |
| topic | Apomorphine-induced stereotypic behavior test Exenatide Nonalcoholic fatty liver Psychosis |
| url | http://www.sciencedirect.com/science/article/pii/S1607551X14001399 |
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