PLOD Family: A Novel Biomarker for Prognosis and Personalized Treatment in Soft Tissue Sarcoma
Despite various treatment attempts, the heterogenous group of soft tissue sarcomata (STS) with more than 100 subtypes still shows poor outcomes. Therefore, effective biomarkers for prognosis prediction and personalized treatment are of high importance. The Procollagen-Lysine, 2-Oxoglutarate 5-Dioxyg...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/5/787 |
| _version_ | 1797499661206945792 |
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| author | Siming Gong Nikolas Schopow Yingjuan Duan Changwu Wu Sonja Kallendrusch Georg Osterhoff |
| author_facet | Siming Gong Nikolas Schopow Yingjuan Duan Changwu Wu Sonja Kallendrusch Georg Osterhoff |
| author_sort | Siming Gong |
| collection | DOAJ |
| description | Despite various treatment attempts, the heterogenous group of soft tissue sarcomata (STS) with more than 100 subtypes still shows poor outcomes. Therefore, effective biomarkers for prognosis prediction and personalized treatment are of high importance. The Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase (PLOD) gene family, which is related to multiple cancer entities, consists of three members which encode important enzymes for the formation of connective tissue. The relation to STS, however, has not yet been explored. In this study, data from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases were used to analyze the role of PLOD1–3 in STS. It was found that an overexpression of PLOD family members correlates with poor prognosis, which might be due to an increased infiltration of immune-related cells in the tumor microenvironment. In STS, the expression of PLOD genes could be a novel biomarker for prognosis and a personalized, more aggressive treatment in these patients. |
| first_indexed | 2024-03-10T03:50:37Z |
| format | Article |
| id | doaj.art-c45b29a53d5043a09c650111dfe17763 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T03:50:37Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-c45b29a53d5043a09c650111dfe177632023-11-23T11:09:25ZengMDPI AGGenes2073-44252022-04-0113578710.3390/genes13050787PLOD Family: A Novel Biomarker for Prognosis and Personalized Treatment in Soft Tissue SarcomaSiming Gong0Nikolas Schopow1Yingjuan Duan2Changwu Wu3Sonja Kallendrusch4Georg Osterhoff5Institute of Anatomy, University of Leipzig, Liebigstraße 13, 04103 Leipzig, GermanyInstitute of Anatomy, University of Leipzig, Liebigstraße 13, 04103 Leipzig, GermanyFaculty of Chemistry and Mineralogy, University of Leipzig, Johannisallee 29, 04103 Leipzig, GermanyInstitute of Anatomy, University of Leipzig, Liebigstraße 13, 04103 Leipzig, GermanyInstitute of Anatomy, University of Leipzig, Liebigstraße 13, 04103 Leipzig, GermanySarcoma Center, Department for Orthopedics, Trauma Surgery and Reconstructive Surgery, University Hospital Leipzig, Liebigstraße 20, 04103 Leipzig, GermanyDespite various treatment attempts, the heterogenous group of soft tissue sarcomata (STS) with more than 100 subtypes still shows poor outcomes. Therefore, effective biomarkers for prognosis prediction and personalized treatment are of high importance. The Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase (PLOD) gene family, which is related to multiple cancer entities, consists of three members which encode important enzymes for the formation of connective tissue. The relation to STS, however, has not yet been explored. In this study, data from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases were used to analyze the role of PLOD1–3 in STS. It was found that an overexpression of PLOD family members correlates with poor prognosis, which might be due to an increased infiltration of immune-related cells in the tumor microenvironment. In STS, the expression of PLOD genes could be a novel biomarker for prognosis and a personalized, more aggressive treatment in these patients.https://www.mdpi.com/2073-4425/13/5/787PLOD familysoft tissue sarcomaprognostictumor microenvironmentimmune infiltrationpersonalized treatment |
| spellingShingle | Siming Gong Nikolas Schopow Yingjuan Duan Changwu Wu Sonja Kallendrusch Georg Osterhoff PLOD Family: A Novel Biomarker for Prognosis and Personalized Treatment in Soft Tissue Sarcoma Genes PLOD family soft tissue sarcoma prognostic tumor microenvironment immune infiltration personalized treatment |
| title | PLOD Family: A Novel Biomarker for Prognosis and Personalized Treatment in Soft Tissue Sarcoma |
| title_full | PLOD Family: A Novel Biomarker for Prognosis and Personalized Treatment in Soft Tissue Sarcoma |
| title_fullStr | PLOD Family: A Novel Biomarker for Prognosis and Personalized Treatment in Soft Tissue Sarcoma |
| title_full_unstemmed | PLOD Family: A Novel Biomarker for Prognosis and Personalized Treatment in Soft Tissue Sarcoma |
| title_short | PLOD Family: A Novel Biomarker for Prognosis and Personalized Treatment in Soft Tissue Sarcoma |
| title_sort | plod family a novel biomarker for prognosis and personalized treatment in soft tissue sarcoma |
| topic | PLOD family soft tissue sarcoma prognostic tumor microenvironment immune infiltration personalized treatment |
| url | https://www.mdpi.com/2073-4425/13/5/787 |
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