Association of IFN-γ +874 A/T SNP and hypermethylation of the -53 CpG site with tuberculosis susceptibility

Association of IFN-γ +874 A/T SNP and hypermethylation of the -53 CpG site with tuberculosis susceptibility

IntroductionTuberculosis (TB) is now the 2nd leading infectious killer after COVID-19 and the 13th leading cause of death worldwide. Moreover, TB is a lethal combination for HIV-patients. Th1 responses and particularly IFN-γ are crucial for immune protection against Mycobacterium tuberculosis infect...

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Main Authors: Guadalupe Inés Álvarez, Rodrigo Emanuel Hernández Del Pino, Angela María Barbero, Martín Andrés Estermann, Josefina Celano, Rosa María Musella, Domingo Juan Palmero, Verónica Edith García, Virginia Pasquinelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
tuberculosis
IFNg
SNPs
methylation
susceptibility
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2023.1080100/full

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