Expression and prognosis of GNG5 in lower-grade glioma using public database
Background: Glioma is the most common primary brain tumor, but its therapeutic effect is not very ideal up to now. The point of this study was to recognize the potential gene involved in lower-grade glioma (LGG) and to promote the treatment and prognosis for LGG patients. Method: During the investig...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | All Life |
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| Online Access: | http://dx.doi.org/10.1080/26895293.2022.2131636 |
| _version_ | 1827304008604188672 |
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| author | Xiaohui Tan Huandi Zhou Liubing Hou Haonan Li Junling Liu Yuehong Li Xiaoying Xue |
| author_facet | Xiaohui Tan Huandi Zhou Liubing Hou Haonan Li Junling Liu Yuehong Li Xiaoying Xue |
| author_sort | Xiaohui Tan |
| collection | DOAJ |
| description | Background: Glioma is the most common primary brain tumor, but its therapeutic effect is not very ideal up to now. The point of this study was to recognize the potential gene involved in lower-grade glioma (LGG) and to promote the treatment and prognosis for LGG patients. Method: During the investigation, we first studied the differential expression and the survival analysis of GNG5 in patients with glioma, LGG, and GBM, respectively. Then, independent prognostic analysis, the clinical relevance characteristics and the differential expressed genes (DEGs) were also evaluated. In addition, Metascape and GSEA analyses were carried out to achieve potential mechanism. Co-expression and immune infiltration analysis were finally conducted. Results: The results indicated that GNG5 as an independent prognostic indicator was negatively associated with the overall survival of LGG patients. Metascape and GSEA analyses showed that GNG5 may participate in complement and coagulation cascades pathway. The co-expression analysis was concluded that GNG5 was positively correlated with the following factors: C4B, PLAU, C1R, C1QC, C4A, SERPINA1, C1QB, CFI, C3. Conclusions: This study demonstrated that the highly expression of GNG5 in LGG may lead to poor prognosis. Besides, our research also revealed that GNG5 may be a promising immune-related biomarker for LGG patients. |
| first_indexed | 2024-03-08T16:59:14Z |
| format | Article |
| id | doaj.art-c45c13cb9cc24ed4b9944e17266a39d3 |
| institution | Directory Open Access Journal |
| issn | 2689-5307 |
| language | English |
| last_indexed | 2024-04-24T17:12:01Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
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| spelling | doaj.art-c45c13cb9cc24ed4b9944e17266a39d32024-03-28T09:48:51ZengTaylor & Francis GroupAll Life2689-53072022-12-011511101111610.1080/26895293.2022.21316362131636Expression and prognosis of GNG5 in lower-grade glioma using public databaseXiaohui Tan0Huandi Zhou1Liubing Hou2Haonan Li3Junling Liu4Yuehong Li5Xiaoying Xue6Department of Radiotherapy, The Second Hospital of Hebei Medical UniversityDepartment of Radiotherapy, The Second Hospital of Hebei Medical UniversityDepartment of Radiotherapy, The Second Hospital of Hebei Medical UniversityDepartment of Radiotherapy, The Second Hospital of Hebei Medical UniversityDepartment of Radiotherapy, The Second Hospital of Hebei Medical UniversityDepartment of Pathology, The Second Hospital of Hebei Medical UniversityDepartment of Radiotherapy, The Second Hospital of Hebei Medical UniversityBackground: Glioma is the most common primary brain tumor, but its therapeutic effect is not very ideal up to now. The point of this study was to recognize the potential gene involved in lower-grade glioma (LGG) and to promote the treatment and prognosis for LGG patients. Method: During the investigation, we first studied the differential expression and the survival analysis of GNG5 in patients with glioma, LGG, and GBM, respectively. Then, independent prognostic analysis, the clinical relevance characteristics and the differential expressed genes (DEGs) were also evaluated. In addition, Metascape and GSEA analyses were carried out to achieve potential mechanism. Co-expression and immune infiltration analysis were finally conducted. Results: The results indicated that GNG5 as an independent prognostic indicator was negatively associated with the overall survival of LGG patients. Metascape and GSEA analyses showed that GNG5 may participate in complement and coagulation cascades pathway. The co-expression analysis was concluded that GNG5 was positively correlated with the following factors: C4B, PLAU, C1R, C1QC, C4A, SERPINA1, C1QB, CFI, C3. Conclusions: This study demonstrated that the highly expression of GNG5 in LGG may lead to poor prognosis. Besides, our research also revealed that GNG5 may be a promising immune-related biomarker for LGG patients.http://dx.doi.org/10.1080/26895293.2022.2131636lower-grade gliomaprognosisbiomarkergng5 |
| spellingShingle | Xiaohui Tan Huandi Zhou Liubing Hou Haonan Li Junling Liu Yuehong Li Xiaoying Xue Expression and prognosis of GNG5 in lower-grade glioma using public database All Life lower-grade glioma prognosis biomarker gng5 |
| title | Expression and prognosis of GNG5 in lower-grade glioma using public database |
| title_full | Expression and prognosis of GNG5 in lower-grade glioma using public database |
| title_fullStr | Expression and prognosis of GNG5 in lower-grade glioma using public database |
| title_full_unstemmed | Expression and prognosis of GNG5 in lower-grade glioma using public database |
| title_short | Expression and prognosis of GNG5 in lower-grade glioma using public database |
| title_sort | expression and prognosis of gng5 in lower grade glioma using public database |
| topic | lower-grade glioma prognosis biomarker gng5 |
| url | http://dx.doi.org/10.1080/26895293.2022.2131636 |
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