Brain Beta-Catenin Signalling During Stress and Depression
Beta-catenin is a protein with dual functions in the cell, playing a role in both adhesion between cells as well as gene transcription via the canonical Wnt signalling pathway. In the canonical Wnt signalling pathway, beta-catenin again plays multiple roles. In the embryonic stage, the regulation of...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Cell Physiol Biochem Press GmbH & Co KG
2018-02-01
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| Series: | Neurosignals |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/487764 |
| _version_ | 1818921851529723904 |
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| author | Chuin Hau Teo Tomoko Soga Ishwar S. Parhar |
| author_facet | Chuin Hau Teo Tomoko Soga Ishwar S. Parhar |
| author_sort | Chuin Hau Teo |
| collection | DOAJ |
| description | Beta-catenin is a protein with dual functions in the cell, playing a role in both adhesion between cells as well as gene transcription via the canonical Wnt signalling pathway. In the canonical Wnt signalling pathway, beta-catenin again plays multiple roles. In the embryonic stage, the regulation of beta-catenin levels activates genes that govern cell proliferation and differentiation. In an adult organism, beta-catenin continues to regulate the cell cycle – as a result over-expression of beta-catenin may lead to cancer. In the brain, dysfunctions in Wnt signalling related to beta-catenin levels may also cause various pathological conditions like Alzheimer’s disease, Parkinson’s disease, and depression. Beta-catenin can be influenced by stressful conditions and increases in glucocorticoid levels. In addition, beta-catenin can be regulated by neurotransmitters such as serotonin and dopamine. Fluctuations in beta-catenin in brain regions under duress have been associated with depressive-like behaviours. It is theorized that the change in behaviour can be attributed to the regulation of Dicer by beta-catenin. Dicer, a protein that produces micro-RNAs in the cell, is a target gene for beta-catenin. Amongst the micro-RNA that it produces are those involved in stress resilience. In this way, beta-catenin has taken its place in the well-studied biochemistry of stress and depression, and future research into this interesting protein may yet yield fruitful results in that field. |
| first_indexed | 2024-12-20T01:44:13Z |
| format | Article |
| id | doaj.art-c45e63a5e1ce4912a2e60156585b0bb4 |
| institution | Directory Open Access Journal |
| issn | 1424-862X 1424-8638 |
| language | English |
| last_indexed | 2024-12-20T01:44:13Z |
| publishDate | 2018-02-01 |
| publisher | Cell Physiol Biochem Press GmbH & Co KG |
| record_format | Article |
| series | Neurosignals |
| spelling | doaj.art-c45e63a5e1ce4912a2e60156585b0bb42022-12-21T19:57:49ZengCell Physiol Biochem Press GmbH & Co KGNeurosignals1424-862X1424-86382018-02-01261314210.1159/000487764487764Brain Beta-Catenin Signalling During Stress and DepressionChuin Hau TeoTomoko SogaIshwar S. ParharBeta-catenin is a protein with dual functions in the cell, playing a role in both adhesion between cells as well as gene transcription via the canonical Wnt signalling pathway. In the canonical Wnt signalling pathway, beta-catenin again plays multiple roles. In the embryonic stage, the regulation of beta-catenin levels activates genes that govern cell proliferation and differentiation. In an adult organism, beta-catenin continues to regulate the cell cycle – as a result over-expression of beta-catenin may lead to cancer. In the brain, dysfunctions in Wnt signalling related to beta-catenin levels may also cause various pathological conditions like Alzheimer’s disease, Parkinson’s disease, and depression. Beta-catenin can be influenced by stressful conditions and increases in glucocorticoid levels. In addition, beta-catenin can be regulated by neurotransmitters such as serotonin and dopamine. Fluctuations in beta-catenin in brain regions under duress have been associated with depressive-like behaviours. It is theorized that the change in behaviour can be attributed to the regulation of Dicer by beta-catenin. Dicer, a protein that produces micro-RNAs in the cell, is a target gene for beta-catenin. Amongst the micro-RNA that it produces are those involved in stress resilience. In this way, beta-catenin has taken its place in the well-studied biochemistry of stress and depression, and future research into this interesting protein may yet yield fruitful results in that field.https://www.karger.com/Article/FullText/487764WntGSK3βGlucocorticoidsSerotoninmiRNA |
| spellingShingle | Chuin Hau Teo Tomoko Soga Ishwar S. Parhar Brain Beta-Catenin Signalling During Stress and Depression Neurosignals Wnt GSK3β Glucocorticoids Serotonin miRNA |
| title | Brain Beta-Catenin Signalling During Stress and Depression |
| title_full | Brain Beta-Catenin Signalling During Stress and Depression |
| title_fullStr | Brain Beta-Catenin Signalling During Stress and Depression |
| title_full_unstemmed | Brain Beta-Catenin Signalling During Stress and Depression |
| title_short | Brain Beta-Catenin Signalling During Stress and Depression |
| title_sort | brain beta catenin signalling during stress and depression |
| topic | Wnt GSK3β Glucocorticoids Serotonin miRNA |
| url | https://www.karger.com/Article/FullText/487764 |
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