NLRP3 Inflammasome: Potential Role in Obesity Related Low-Grade Inflammation and Insulin Resistance in Skeletal Muscle
Among multiple mechanisms, low-grade inflammation is critical for the development of insulin resistance as a feature of type 2 diabetes. The nucleotide-binding oligomerization domain-like receptor family (NOD-like) pyrin domain containing 3 (NLRP3) inflammasome has been linked to the development of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/6/3254 |
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| author | Gonzalo Jorquera Javier Russell Matías Monsalves-Álvarez Gonzalo Cruz Denisse Valladares-Ide Carla Basualto-Alarcón Genaro Barrientos Manuel Estrada Paola Llanos |
| author_facet | Gonzalo Jorquera Javier Russell Matías Monsalves-Álvarez Gonzalo Cruz Denisse Valladares-Ide Carla Basualto-Alarcón Genaro Barrientos Manuel Estrada Paola Llanos |
| author_sort | Gonzalo Jorquera |
| collection | DOAJ |
| description | Among multiple mechanisms, low-grade inflammation is critical for the development of insulin resistance as a feature of type 2 diabetes. The nucleotide-binding oligomerization domain-like receptor family (NOD-like) pyrin domain containing 3 (NLRP3) inflammasome has been linked to the development of insulin resistance in various tissues; however, its role in the development of insulin resistance in the skeletal muscle has not been explored in depth. Currently, there is limited evidence that supports the pathological role of NLRP3 inflammasome activation in glucose handling in the skeletal muscle of obese individuals. Here, we have centered our focus on insulin signaling in skeletal muscle, which is the main site of postprandial glucose disposal in humans. We discuss the current evidence showing that the NLRP3 inflammasome disturbs glucose homeostasis. We also review how NLRP3-associated interleukin and its gasdermin D-mediated efflux could affect insulin-dependent intracellular pathways. Finally, we address pharmacological NLRP3 inhibitors that may have a therapeutical use in obesity-related metabolic alterations. |
| first_indexed | 2024-03-10T13:00:20Z |
| format | Article |
| id | doaj.art-c45e762c6e3e40b7ab31bc282aa00574 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T13:00:20Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c45e762c6e3e40b7ab31bc282aa005742023-11-21T11:37:18ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-03-01226325410.3390/ijms22063254NLRP3 Inflammasome: Potential Role in Obesity Related Low-Grade Inflammation and Insulin Resistance in Skeletal MuscleGonzalo Jorquera0Javier Russell1Matías Monsalves-Álvarez2Gonzalo Cruz3Denisse Valladares-Ide4Carla Basualto-Alarcón5Genaro Barrientos6Manuel Estrada7Paola Llanos8Centro de Neurobiología y Fisiopatología Integrativa (CENFI), Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2360102, ChileEscuela de Pedagogía en Educación Física, Facultad de Educación, Universidad Autónoma de Chile, Santiago 8900000, ChileInstituto de Ciencias de la Salud, Universidad de O’Higgins, Rancagua 2820000, ChileCentro de Neurobiología y Fisiopatología Integrativa (CENFI), Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2360102, ChileInstituto de Ciencias de la Salud, Universidad de O’Higgins, Rancagua 2820000, ChileDepartamento de Ciencias de la Salud, Universidad de Aysén, Coyhaique 5951537, ChilePrograma de Fisiología y Biofísica, ICBM, Facultad de Medicina, Universidad de Chile, Santiago 8380453, ChilePrograma de Fisiología y Biofísica, ICBM, Facultad de Medicina, Universidad de Chile, Santiago 8380453, ChileCentro de Estudios en Ejercicio, Metabolismo y Cáncer, Facultad de Medicina, Universidad de Chile, Santiago 8380453, ChileAmong multiple mechanisms, low-grade inflammation is critical for the development of insulin resistance as a feature of type 2 diabetes. The nucleotide-binding oligomerization domain-like receptor family (NOD-like) pyrin domain containing 3 (NLRP3) inflammasome has been linked to the development of insulin resistance in various tissues; however, its role in the development of insulin resistance in the skeletal muscle has not been explored in depth. Currently, there is limited evidence that supports the pathological role of NLRP3 inflammasome activation in glucose handling in the skeletal muscle of obese individuals. Here, we have centered our focus on insulin signaling in skeletal muscle, which is the main site of postprandial glucose disposal in humans. We discuss the current evidence showing that the NLRP3 inflammasome disturbs glucose homeostasis. We also review how NLRP3-associated interleukin and its gasdermin D-mediated efflux could affect insulin-dependent intracellular pathways. Finally, we address pharmacological NLRP3 inhibitors that may have a therapeutical use in obesity-related metabolic alterations.https://www.mdpi.com/1422-0067/22/6/3254NALP3chronic inflammationmuscleglucose transport |
| spellingShingle | Gonzalo Jorquera Javier Russell Matías Monsalves-Álvarez Gonzalo Cruz Denisse Valladares-Ide Carla Basualto-Alarcón Genaro Barrientos Manuel Estrada Paola Llanos NLRP3 Inflammasome: Potential Role in Obesity Related Low-Grade Inflammation and Insulin Resistance in Skeletal Muscle International Journal of Molecular Sciences NALP3 chronic inflammation muscle glucose transport |
| title | NLRP3 Inflammasome: Potential Role in Obesity Related Low-Grade Inflammation and Insulin Resistance in Skeletal Muscle |
| title_full | NLRP3 Inflammasome: Potential Role in Obesity Related Low-Grade Inflammation and Insulin Resistance in Skeletal Muscle |
| title_fullStr | NLRP3 Inflammasome: Potential Role in Obesity Related Low-Grade Inflammation and Insulin Resistance in Skeletal Muscle |
| title_full_unstemmed | NLRP3 Inflammasome: Potential Role in Obesity Related Low-Grade Inflammation and Insulin Resistance in Skeletal Muscle |
| title_short | NLRP3 Inflammasome: Potential Role in Obesity Related Low-Grade Inflammation and Insulin Resistance in Skeletal Muscle |
| title_sort | nlrp3 inflammasome potential role in obesity related low grade inflammation and insulin resistance in skeletal muscle |
| topic | NALP3 chronic inflammation muscle glucose transport |
| url | https://www.mdpi.com/1422-0067/22/6/3254 |
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