BET bromodomain inhibition rescues PD-1-mediated T-cell exhaustion in acute myeloid leukemia

BET bromodomain inhibition rescues PD-1-mediated T-cell exhaustion in acute myeloid leukemia

Abstract Sustained expression of programmed cell death receptor-1 (PD-1) is correlated with the exhaustion of T cells, and blockade of the PD-1 pathway is an effective immunotherapeutic strategy for treating various cancers. However, response rates are limited, and many patients do not achieve durab...

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Main Authors: Mengjun Zhong, Rili Gao, Ruocong Zhao, Youxue Huang, Cunte Chen, Kehan Li, Xibao Yu, Dingrui Nie, Zheng Chen, Xin Liu, Zhuandi Liu, Shaohua Chen, Yuhong Lu, Zhi Yu, Liang Wang, Peng Li, Chengwu Zeng, Yangqiu Li
Format: Article
Language:English
Published: Nature Publishing Group 2022-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05123-x

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