Challenges in long-term control of hypercalcaemia with denosumab after haematopoietic stem cell transplantation for TNFRSF11A osteoclast-poor autosomal recessive osteopetrosis

Challenges in long-term control of hypercalcaemia with denosumab after haematopoietic stem cell transplantation for TNFRSF11A osteoclast-poor autosomal recessive osteopetrosis

Autosomal recessive osteopetrosis (ARO) is rare, involving increased bone density due to defective osteoclast differentiation or function, with several genetic subtypes. Case: This child with compound heterozygous novel loss-of-function TNFRSF11A pathogenic variants causing osteoclast-poor ARO under...

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Bibliographic Details
Main Authors: Tashunka Taylor-Miller, Ponni Sivaprakasam, Sarah F. Smithson, Colin G. Steward, Christine P. Burren
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Bone Reports
Subjects:
Craniosynostosis
Denosumab
Haematopoietic stem cell transplantation
Hypercalcaemia
Osteopetrosis
TNFRSF11A
Online Access:http://www.sciencedirect.com/science/article/pii/S2352187220304988

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