Diffuse Midline Gliomas Harboring the H3 K27M-Mutation in the Bilateral Thalamus and Midbrain: A Case Report and a Review of the Literature
The diffuse midline glioma H3 K27M-mutant was only added recently to the World Health Organization (WHO) Classification of Tumours of the Central Nervous System. While similar tumors are found in the midline, this particular mutation represents the majority of diffuse gliomas in the brainstem. Cl...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Korean Society of Radiology
2017-12-01
|
| Series: | 대한영상의학회지 |
| Subjects: | |
| Online Access: | https://doi.org/10.3348/jksr.2017.77.6.416 |
| _version_ | 1818495536240525312 |
|---|---|
| author | In Kyeom Kim Jin Woo Kim Yoon Joon Hwang Byung Hoon Lee Jung Wook Seo |
| author_facet | In Kyeom Kim Jin Woo Kim Yoon Joon Hwang Byung Hoon Lee Jung Wook Seo |
| author_sort | In Kyeom Kim |
| collection | DOAJ |
| description | The diffuse midline glioma H3 K27M-mutant was only added recently to the World
Health Organization (WHO) Classification of Tumours of the Central Nervous System.
While similar tumors are found in the midline, this particular mutation represents the
majority of diffuse gliomas in the brainstem. Classified by WHO as grade IV tumors,
these are aggressive and bear a poor prognosis for the patient. This report describes
a case involving a 37-year-old woman with a histologically confirmed diffuse midline glioma H3 K27M-mutant in the bilateral thalamus and midbrain. The following
discussion describes typical characteristics observed with computed tomography
and magnetic resonance imaging. Given the rarity of diffuse intrinsic pontine gliomas
in adults and the general lack of studies investigating this poorly understood entity,
we report critical findings for contribution to the existing scarce literature on the topic. |
| first_indexed | 2024-12-10T18:21:48Z |
| format | Article |
| id | doaj.art-c45efaca13584723820d2ba2617cb624 |
| institution | Directory Open Access Journal |
| issn | 1738-2637 2288-2928 |
| language | English |
| last_indexed | 2024-12-10T18:21:48Z |
| publishDate | 2017-12-01 |
| publisher | The Korean Society of Radiology |
| record_format | Article |
| series | 대한영상의학회지 |
| spelling | doaj.art-c45efaca13584723820d2ba2617cb6242022-12-22T01:38:11ZengThe Korean Society of Radiology대한영상의학회지1738-26372288-29282017-12-01776416420https://doi.org/10.3348/jksr.2017.77.6.416Diffuse Midline Gliomas Harboring the H3 K27M-Mutation in the Bilateral Thalamus and Midbrain: A Case Report and a Review of the LiteratureIn Kyeom Kim0Jin Woo Kim1Yoon Joon Hwang2Byung Hoon Lee3Jung Wook Seo4Department of Radiology, Inje University College of Medicine, Ilsan Paik Hospital, Goyang, KoreaDepartment of Radiology, Inje University College of Medicine, Ilsan Paik Hospital, Goyang, KoreaDepartment of Radiology, Inje University College of Medicine, Ilsan Paik Hospital, Goyang, KoreaDepartment of Radiology, Inje University College of Medicine, Ilsan Paik Hospital, Goyang, KoreaDepartment of Radiology, Inje University College of Medicine, Ilsan Paik Hospital, Goyang, KoreaThe diffuse midline glioma H3 K27M-mutant was only added recently to the World Health Organization (WHO) Classification of Tumours of the Central Nervous System. While similar tumors are found in the midline, this particular mutation represents the majority of diffuse gliomas in the brainstem. Classified by WHO as grade IV tumors, these are aggressive and bear a poor prognosis for the patient. This report describes a case involving a 37-year-old woman with a histologically confirmed diffuse midline glioma H3 K27M-mutant in the bilateral thalamus and midbrain. The following discussion describes typical characteristics observed with computed tomography and magnetic resonance imaging. Given the rarity of diffuse intrinsic pontine gliomas in adults and the general lack of studies investigating this poorly understood entity, we report critical findings for contribution to the existing scarce literature on the topic.https://doi.org/10.3348/jksr.2017.77.6.416brain stem neoplasmsthalamusmidbrainmagnetic resonance imaging |
| spellingShingle | In Kyeom Kim Jin Woo Kim Yoon Joon Hwang Byung Hoon Lee Jung Wook Seo Diffuse Midline Gliomas Harboring the H3 K27M-Mutation in the Bilateral Thalamus and Midbrain: A Case Report and a Review of the Literature 대한영상의학회지 brain stem neoplasms thalamus midbrain magnetic resonance imaging |
| title | Diffuse Midline Gliomas Harboring the H3 K27M-Mutation in the Bilateral Thalamus and Midbrain: A Case Report and a Review of the Literature |
| title_full | Diffuse Midline Gliomas Harboring the H3 K27M-Mutation in the Bilateral Thalamus and Midbrain: A Case Report and a Review of the Literature |
| title_fullStr | Diffuse Midline Gliomas Harboring the H3 K27M-Mutation in the Bilateral Thalamus and Midbrain: A Case Report and a Review of the Literature |
| title_full_unstemmed | Diffuse Midline Gliomas Harboring the H3 K27M-Mutation in the Bilateral Thalamus and Midbrain: A Case Report and a Review of the Literature |
| title_short | Diffuse Midline Gliomas Harboring the H3 K27M-Mutation in the Bilateral Thalamus and Midbrain: A Case Report and a Review of the Literature |
| title_sort | diffuse midline gliomas harboring the h3 k27m mutation in the bilateral thalamus and midbrain a case report and a review of the literature |
| topic | brain stem neoplasms thalamus midbrain magnetic resonance imaging |
| url | https://doi.org/10.3348/jksr.2017.77.6.416 |
| work_keys_str_mv | AT inkyeomkim diffusemidlinegliomasharboringtheh3k27mmutationinthebilateralthalamusandmidbrainacasereportandareviewoftheliterature AT jinwookim diffusemidlinegliomasharboringtheh3k27mmutationinthebilateralthalamusandmidbrainacasereportandareviewoftheliterature AT yoonjoonhwang diffusemidlinegliomasharboringtheh3k27mmutationinthebilateralthalamusandmidbrainacasereportandareviewoftheliterature AT byunghoonlee diffusemidlinegliomasharboringtheh3k27mmutationinthebilateralthalamusandmidbrainacasereportandareviewoftheliterature AT jungwookseo diffusemidlinegliomasharboringtheh3k27mmutationinthebilateralthalamusandmidbrainacasereportandareviewoftheliterature |