Pericytes in Cerebrovascular Diseases: An Emerging Therapeutic Target
Pericytes are functional components of the neurovascular unit (NVU) that are located around the blood vessels, and their roles in the regulation of cerebral health and diseases has been reported. Currently, the potential properties of pericytes as emerging therapeutic targets for cerebrovascular dis...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-11-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2019.00519/full |
| _version_ | 1818117707048943616 |
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| author | Xiaojuan Su Xiaojuan Su Lingyi Huang Yi Qu Yi Qu Dongqiong Xiao Dongqiong Xiao Dezhi Mu Dezhi Mu |
| author_facet | Xiaojuan Su Xiaojuan Su Lingyi Huang Yi Qu Yi Qu Dongqiong Xiao Dongqiong Xiao Dezhi Mu Dezhi Mu |
| author_sort | Xiaojuan Su |
| collection | DOAJ |
| description | Pericytes are functional components of the neurovascular unit (NVU) that are located around the blood vessels, and their roles in the regulation of cerebral health and diseases has been reported. Currently, the potential properties of pericytes as emerging therapeutic targets for cerebrovascular diseases have attracted considerable attention. Nonetheless, few reviews have comprehensively discussed pericytes and their roles in cerebrovascular diseases. Therefore, in this review, we not only summarized and described the basic characteristics of pericytes but also focused on clarifying the new understanding about the roles of pericytes in the pathogenesis of cerebrovascular diseases, including white matter injury (WMI), hypoxic–ischemic brain damage, depression, neovascular insufficiency disease, and Alzheimer’s disease (AD). Furthermore, we summarized the current therapeutic strategies targeting pericytes for cerebrovascular diseases. Collectively, this review is aimed at providing a comprehensive understanding of pericytes and new insights about the use of pericytes as novel therapeutic targets for cerebrovascular diseases. |
| first_indexed | 2024-12-11T04:42:41Z |
| format | Article |
| id | doaj.art-c46029e584764800a7c7a781fded18cd |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-11T04:42:41Z |
| publishDate | 2019-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-c46029e584764800a7c7a781fded18cd2022-12-22T01:20:36ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022019-11-011310.3389/fncel.2019.00519471731Pericytes in Cerebrovascular Diseases: An Emerging Therapeutic TargetXiaojuan Su0Xiaojuan Su1Lingyi Huang2Yi Qu3Yi Qu4Dongqiong Xiao5Dongqiong Xiao6Dezhi Mu7Dezhi Mu8Department of Paediatrics, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, ChinaWest China College of Stomatology, Sichuan University, Chengdu, ChinaDepartment of Paediatrics, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, ChinaDepartment of Paediatrics, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, ChinaDepartment of Paediatrics, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, ChinaPericytes are functional components of the neurovascular unit (NVU) that are located around the blood vessels, and their roles in the regulation of cerebral health and diseases has been reported. Currently, the potential properties of pericytes as emerging therapeutic targets for cerebrovascular diseases have attracted considerable attention. Nonetheless, few reviews have comprehensively discussed pericytes and their roles in cerebrovascular diseases. Therefore, in this review, we not only summarized and described the basic characteristics of pericytes but also focused on clarifying the new understanding about the roles of pericytes in the pathogenesis of cerebrovascular diseases, including white matter injury (WMI), hypoxic–ischemic brain damage, depression, neovascular insufficiency disease, and Alzheimer’s disease (AD). Furthermore, we summarized the current therapeutic strategies targeting pericytes for cerebrovascular diseases. Collectively, this review is aimed at providing a comprehensive understanding of pericytes and new insights about the use of pericytes as novel therapeutic targets for cerebrovascular diseases.https://www.frontiersin.org/article/10.3389/fncel.2019.00519/fullpericytesangiogenesisbasement membraneblood brain barriercerebrovascular disease |
| spellingShingle | Xiaojuan Su Xiaojuan Su Lingyi Huang Yi Qu Yi Qu Dongqiong Xiao Dongqiong Xiao Dezhi Mu Dezhi Mu Pericytes in Cerebrovascular Diseases: An Emerging Therapeutic Target Frontiers in Cellular Neuroscience pericytes angiogenesis basement membrane blood brain barrier cerebrovascular disease |
| title | Pericytes in Cerebrovascular Diseases: An Emerging Therapeutic Target |
| title_full | Pericytes in Cerebrovascular Diseases: An Emerging Therapeutic Target |
| title_fullStr | Pericytes in Cerebrovascular Diseases: An Emerging Therapeutic Target |
| title_full_unstemmed | Pericytes in Cerebrovascular Diseases: An Emerging Therapeutic Target |
| title_short | Pericytes in Cerebrovascular Diseases: An Emerging Therapeutic Target |
| title_sort | pericytes in cerebrovascular diseases an emerging therapeutic target |
| topic | pericytes angiogenesis basement membrane blood brain barrier cerebrovascular disease |
| url | https://www.frontiersin.org/article/10.3389/fncel.2019.00519/full |
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