Chronic Venous Disease during Pregnancy Is Related to Inflammation of the Umbilical Cord: Role of Allograft Inflammatory Factor 1 (AIF-1) and Interleukins 10 (IL-10), IL-12 and IL-18
Chronic venous disease (CVD) is a common condition that affects the veins in the lower limbs, resulting in a variety of symptoms, such as swelling, pain, and varicose veins (VVs). The plenty hormonal, hemodynamic and mechanical changes occurred in pregnancy make women especially vulnerable to suffer...
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MDPI AG
2023-06-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/6/956 |
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| author | Lara Sánchez-Trujillo Oscar Fraile-Martinez Cielo García-Montero Luis M. García-Puente Luis G. Guijarro Diego De Leon-Oliva Diego Liviu Boaru David Gardón-Alburquerque María del Val Toledo Lobo Mar Royuela Ignacio García-Tuñón Antonio Rios-Parra Juan A. De León-Luis Coral Bravo Melchor Álvarez-Mon Julia Bujan Miguel A. Saez Natalio García-Honduvilla Miguel A. Ortega |
| author_facet | Lara Sánchez-Trujillo Oscar Fraile-Martinez Cielo García-Montero Luis M. García-Puente Luis G. Guijarro Diego De Leon-Oliva Diego Liviu Boaru David Gardón-Alburquerque María del Val Toledo Lobo Mar Royuela Ignacio García-Tuñón Antonio Rios-Parra Juan A. De León-Luis Coral Bravo Melchor Álvarez-Mon Julia Bujan Miguel A. Saez Natalio García-Honduvilla Miguel A. Ortega |
| author_sort | Lara Sánchez-Trujillo |
| collection | DOAJ |
| description | Chronic venous disease (CVD) is a common condition that affects the veins in the lower limbs, resulting in a variety of symptoms, such as swelling, pain, and varicose veins (VVs). The plenty hormonal, hemodynamic and mechanical changes occurred in pregnancy make women especially vulnerable to suffer from this condition in this period. Previous works have identified that CVD is associated with an increased inflammatory milieu and significant damage in maternofetal tissues, such as the umbilical cord. However, the inflammatory status of this structure in these patients has not been studied yet. Thus, the aim of the present study was to examine gene and protein expression of a set of inflammatory markers—Allograft inflammatory factor 1 (AIF-1), the proinflammatory cytokines interleukin 12A (IL-12A) and IL-18 and the anti-inflammatory product IL-10—in the umbilical cord of women with CVD during pregnancy (N = 62) and healthy pregnant women (HC; N = 52) by the use of real time qPCR and immunohistochemistry (IHC). Our results demonstrate that the umbilical cord tissue from CVD women exhibit an increased expression of AIF-1, IL-12A and IL-18 along with a decrease in IL-10. Therefore, our study suggests an inflammatory status of this structure related to CVD. Further studies should be conducted to evaluate the expression of other inflammatory markers, as well as to analyze the maternofetal impact of these findings. |
| first_indexed | 2024-03-11T02:16:43Z |
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| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-11T02:16:43Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
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| series | Journal of Personalized Medicine |
| spelling | doaj.art-c460fdd5a3b14bba93fcd49438aa28e32023-11-18T11:11:05ZengMDPI AGJournal of Personalized Medicine2075-44262023-06-0113695610.3390/jpm13060956Chronic Venous Disease during Pregnancy Is Related to Inflammation of the Umbilical Cord: Role of Allograft Inflammatory Factor 1 (AIF-1) and Interleukins 10 (IL-10), IL-12 and IL-18Lara Sánchez-Trujillo0Oscar Fraile-Martinez1Cielo García-Montero2Luis M. García-Puente3Luis G. Guijarro4Diego De Leon-Oliva5Diego Liviu Boaru6David Gardón-Alburquerque7María del Val Toledo Lobo8Mar Royuela9Ignacio García-Tuñón10Antonio Rios-Parra11Juan A. De León-Luis12Coral Bravo13Melchor Álvarez-Mon14Julia Bujan15Miguel A. Saez16Natalio García-Honduvilla17Miguel A. Ortega18Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainRamón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, SpainDepartment of Biomedicine and Biotechnology, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Biomedicine and Biotechnology, University of Alcalá, 28801 Alcalá de Henares, SpainRamón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, SpainDepartment of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, SpainDepartment of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainChronic venous disease (CVD) is a common condition that affects the veins in the lower limbs, resulting in a variety of symptoms, such as swelling, pain, and varicose veins (VVs). The plenty hormonal, hemodynamic and mechanical changes occurred in pregnancy make women especially vulnerable to suffer from this condition in this period. Previous works have identified that CVD is associated with an increased inflammatory milieu and significant damage in maternofetal tissues, such as the umbilical cord. However, the inflammatory status of this structure in these patients has not been studied yet. Thus, the aim of the present study was to examine gene and protein expression of a set of inflammatory markers—Allograft inflammatory factor 1 (AIF-1), the proinflammatory cytokines interleukin 12A (IL-12A) and IL-18 and the anti-inflammatory product IL-10—in the umbilical cord of women with CVD during pregnancy (N = 62) and healthy pregnant women (HC; N = 52) by the use of real time qPCR and immunohistochemistry (IHC). Our results demonstrate that the umbilical cord tissue from CVD women exhibit an increased expression of AIF-1, IL-12A and IL-18 along with a decrease in IL-10. Therefore, our study suggests an inflammatory status of this structure related to CVD. Further studies should be conducted to evaluate the expression of other inflammatory markers, as well as to analyze the maternofetal impact of these findings.https://www.mdpi.com/2075-4426/13/6/956chronic venous disease (CVD)pregnancyumbilical cordinflammationAllograft inflammatory factor 1 (AIF-1)Interleukin 10 (IL-10) |
| spellingShingle | Lara Sánchez-Trujillo Oscar Fraile-Martinez Cielo García-Montero Luis M. García-Puente Luis G. Guijarro Diego De Leon-Oliva Diego Liviu Boaru David Gardón-Alburquerque María del Val Toledo Lobo Mar Royuela Ignacio García-Tuñón Antonio Rios-Parra Juan A. De León-Luis Coral Bravo Melchor Álvarez-Mon Julia Bujan Miguel A. Saez Natalio García-Honduvilla Miguel A. Ortega Chronic Venous Disease during Pregnancy Is Related to Inflammation of the Umbilical Cord: Role of Allograft Inflammatory Factor 1 (AIF-1) and Interleukins 10 (IL-10), IL-12 and IL-18 Journal of Personalized Medicine chronic venous disease (CVD) pregnancy umbilical cord inflammation Allograft inflammatory factor 1 (AIF-1) Interleukin 10 (IL-10) |
| title | Chronic Venous Disease during Pregnancy Is Related to Inflammation of the Umbilical Cord: Role of Allograft Inflammatory Factor 1 (AIF-1) and Interleukins 10 (IL-10), IL-12 and IL-18 |
| title_full | Chronic Venous Disease during Pregnancy Is Related to Inflammation of the Umbilical Cord: Role of Allograft Inflammatory Factor 1 (AIF-1) and Interleukins 10 (IL-10), IL-12 and IL-18 |
| title_fullStr | Chronic Venous Disease during Pregnancy Is Related to Inflammation of the Umbilical Cord: Role of Allograft Inflammatory Factor 1 (AIF-1) and Interleukins 10 (IL-10), IL-12 and IL-18 |
| title_full_unstemmed | Chronic Venous Disease during Pregnancy Is Related to Inflammation of the Umbilical Cord: Role of Allograft Inflammatory Factor 1 (AIF-1) and Interleukins 10 (IL-10), IL-12 and IL-18 |
| title_short | Chronic Venous Disease during Pregnancy Is Related to Inflammation of the Umbilical Cord: Role of Allograft Inflammatory Factor 1 (AIF-1) and Interleukins 10 (IL-10), IL-12 and IL-18 |
| title_sort | chronic venous disease during pregnancy is related to inflammation of the umbilical cord role of allograft inflammatory factor 1 aif 1 and interleukins 10 il 10 il 12 and il 18 |
| topic | chronic venous disease (CVD) pregnancy umbilical cord inflammation Allograft inflammatory factor 1 (AIF-1) Interleukin 10 (IL-10) |
| url | https://www.mdpi.com/2075-4426/13/6/956 |
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